STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sufSCysteine desulfurase, SufS family protein; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)    
Predicted Functional Partners:
sufC
sufC: FeS assembly ATPase SufC.
 
  
 0.988
sufD
sufD: FeS assembly protein SufD.
 
 
 0.983
sufB
sufB: FeS assembly protein SufB.
 
 
 0.973
nifU
nifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.942
trxB
TRX_reduct: thioredoxin-disulfide reductase.
 
 
  0.921
selD
Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP.
    
 0.912
csdE
feS_syn_CsdE: cysteine desulfurase, sulfur acceptor subunit CsdE.
 
 0.911
sufE
Cysteine desulfuration protein sufE; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.
 
 0.909
metB
O-succinylhomoserine (thiol)-lyase; Cystathionine gamma-lyase-like protein; O_succ_thio_ly: O-succinylhomoserine (thiol)-lyase.
     
 0.902
sufA
Iron-sulfur cluster assembly accessory family protein; Belongs to the HesB/IscA family.
 
 
 0.820
Your Current Organism:
Yersinia intermedia
NCBI taxonomy Id: 631
Other names: ATCC 29909, CCUG 11292, CIP 80.28, DSM 18517, JCM 7579, NCTC 11469, Y. intermedia, strain 3953, strain Bottone 48, strain Chester 48
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