node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIC19444.1 | EIC19967.1 | Thi970DRAFT_04966 | Thi970DRAFT_03578 | Folylpolyglutamate synthase; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | 0.411 |
EIC19444.1 | glyA | Thi970DRAFT_04966 | Thi970DRAFT_04939 | Folylpolyglutamate synthase; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.729 |
EIC19444.1 | rlmL | Thi970DRAFT_04966 | Thi970DRAFT_04326 | Folylpolyglutamate synthase; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Putative N6-adenine-specific DNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.413 |
EIC19967.1 | EIC19444.1 | Thi970DRAFT_03578 | Thi970DRAFT_04966 | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | Folylpolyglutamate synthase; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.411 |
EIC19967.1 | EIC21195.1 | Thi970DRAFT_03578 | Thi970DRAFT_01384 | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | 0.598 |
EIC19967.1 | dut | Thi970DRAFT_03578 | Thi970DRAFT_03501 | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.443 |
EIC19967.1 | gcvT | Thi970DRAFT_03578 | Thi970DRAFT_04540 | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.455 |
EIC19967.1 | glyA | Thi970DRAFT_03578 | Thi970DRAFT_04939 | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.422 |
EIC19967.1 | rlmL | Thi970DRAFT_03578 | Thi970DRAFT_04326 | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | Putative N6-adenine-specific DNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.451 |
EIC21195.1 | EIC19967.1 | Thi970DRAFT_01384 | Thi970DRAFT_03578 | Sulfur relay protein, TusE/DsrC/DsvC family; Part of a sulfur-relay system. | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | 0.598 |
dut | EIC19967.1 | Thi970DRAFT_03501 | Thi970DRAFT_03578 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | 0.443 |
dut | rlmL | Thi970DRAFT_03501 | Thi970DRAFT_04326 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative N6-adenine-specific DNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.443 |
gcvT | EIC19967.1 | Thi970DRAFT_04540 | Thi970DRAFT_03578 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | 0.455 |
gcvT | glyA | Thi970DRAFT_04540 | Thi970DRAFT_04939 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
gcvT | rlmL | Thi970DRAFT_04540 | Thi970DRAFT_04326 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Putative N6-adenine-specific DNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.508 |
glyA | EIC19444.1 | Thi970DRAFT_04939 | Thi970DRAFT_04966 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Folylpolyglutamate synthase; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.729 |
glyA | EIC19967.1 | Thi970DRAFT_04939 | Thi970DRAFT_03578 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative SAM-dependent methyltransferase; PFAM: S-adenosylmethionine-dependent methyltransferase. | 0.422 |
glyA | gcvT | Thi970DRAFT_04939 | Thi970DRAFT_04540 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
glyA | rlmL | Thi970DRAFT_04939 | Thi970DRAFT_04326 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative N6-adenine-specific DNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | 0.438 |
rlmL | EIC19444.1 | Thi970DRAFT_04326 | Thi970DRAFT_04966 | Putative N6-adenine-specific DNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. | Folylpolyglutamate synthase; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.413 |