node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIC19885.1 | EIC21140.1 | Thi970DRAFT_03491 | Thi970DRAFT_04829 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | 0.564 |
EIC19885.1 | EIC21616.1 | Thi970DRAFT_03491 | Thi970DRAFT_01832 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PFAM: Protein of unknown function (DUF3706). | 0.665 |
EIC19885.1 | guaA | Thi970DRAFT_03491 | Thi970DRAFT_02944 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.968 |
EIC19885.1 | purA | Thi970DRAFT_03491 | Thi970DRAFT_03596 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.819 |
EIC19885.1 | purH | Thi970DRAFT_03491 | Thi970DRAFT_01163 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.617 |
EIC21049.1 | EIC21140.1 | Thi970DRAFT_04733 | Thi970DRAFT_04829 | Flagellar basal body-associated protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | 0.590 |
EIC21140.1 | EIC19885.1 | Thi970DRAFT_04829 | Thi970DRAFT_03491 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.564 |
EIC21140.1 | EIC21049.1 | Thi970DRAFT_04829 | Thi970DRAFT_04733 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | Flagellar basal body-associated protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. | 0.590 |
EIC21140.1 | EIC21616.1 | Thi970DRAFT_04829 | Thi970DRAFT_01832 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | PFAM: Protein of unknown function (DUF3706). | 0.593 |
EIC21140.1 | EIC22031.1 | Thi970DRAFT_04829 | Thi970DRAFT_02272 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | Putative nuleotide-utilizing enzyme, moeA; PFAM: Probable molybdopterin binding domain. | 0.609 |
EIC21140.1 | EIC22143.1 | Thi970DRAFT_04829 | Thi970DRAFT_02393 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | Flagellar basal body-associated protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. | 0.590 |
EIC21140.1 | EIC23544.1 | Thi970DRAFT_04829 | Thi970DRAFT_01215 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | PFAM: Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA C-terminal domain; Belongs to the CinA family. | 0.609 |
EIC21140.1 | guaA | Thi970DRAFT_04829 | Thi970DRAFT_02944 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.853 |
EIC21140.1 | nadD | Thi970DRAFT_04829 | Thi970DRAFT_02950 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | Nicotinate/nicotinamide nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.577 |
EIC21140.1 | purA | Thi970DRAFT_04829 | Thi970DRAFT_03596 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.576 |
EIC21140.1 | purH | Thi970DRAFT_04829 | Thi970DRAFT_01163 | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.570 |
EIC21616.1 | EIC19885.1 | Thi970DRAFT_01832 | Thi970DRAFT_03491 | PFAM: Protein of unknown function (DUF3706). | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.665 |
EIC21616.1 | EIC21140.1 | Thi970DRAFT_01832 | Thi970DRAFT_04829 | PFAM: Protein of unknown function (DUF3706). | Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homolog. | 0.593 |
EIC21616.1 | guaA | Thi970DRAFT_01832 | Thi970DRAFT_02944 | PFAM: Protein of unknown function (DUF3706). | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.994 |
EIC21616.1 | purA | Thi970DRAFT_01832 | Thi970DRAFT_03596 | PFAM: Protein of unknown function (DUF3706). | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.717 |