node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIC19416.1 | EIC19417.1 | Thi970DRAFT_04936 | Thi970DRAFT_04937 | PFAM: Glutamine amidotransferases class-II. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.826 |
EIC19416.1 | EIC20227.1 | Thi970DRAFT_04936 | Thi970DRAFT_03851 | PFAM: Glutamine amidotransferases class-II. | Selenocysteine lyase; PFAM: Aminotransferase class-V. | 0.711 |
EIC19416.1 | EIC20686.1 | Thi970DRAFT_04936 | Thi970DRAFT_04340 | PFAM: Glutamine amidotransferases class-II. | Hypothetical protein; PFAM: Formylglycine-generating sulfatase enzyme; PEGA domain. | 0.534 |
EIC19416.1 | EIC20695.1 | Thi970DRAFT_04936 | Thi970DRAFT_04350 | PFAM: Glutamine amidotransferases class-II. | Hypothetical protein; PFAM: Formylglycine-generating sulfatase enzyme; PEGA domain. | 0.534 |
EIC19416.1 | EIC21438.1 | Thi970DRAFT_04936 | Thi970DRAFT_01646 | PFAM: Glutamine amidotransferases class-II. | Hypothetical protein. | 0.529 |
EIC19416.1 | EIC23051.1 | Thi970DRAFT_04936 | Thi970DRAFT_00702 | PFAM: Glutamine amidotransferases class-II. | Putative methyltransferase; PFAM: Uncharacterized conserved protein (DUF2260); TIGRFAM: probable methyltransferase. | 0.810 |
EIC19416.1 | EIC23052.1 | Thi970DRAFT_04936 | Thi970DRAFT_00703 | PFAM: Glutamine amidotransferases class-II. | TIGR03440 family protein; PFAM: Formylglycine-generating sulfatase enzyme; TIGRFAM: TIGR03440 family protein. | 0.557 |
EIC19416.1 | argB | Thi970DRAFT_04936 | Thi970DRAFT_03499 | PFAM: Glutamine amidotransferases class-II. | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | 0.621 |
EIC19416.1 | glyA | Thi970DRAFT_04936 | Thi970DRAFT_04939 | PFAM: Glutamine amidotransferases class-II. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.590 |
EIC19416.1 | nrdR | Thi970DRAFT_04936 | Thi970DRAFT_04938 | PFAM: Glutamine amidotransferases class-II. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.786 |
EIC19417.1 | EIC19416.1 | Thi970DRAFT_04937 | Thi970DRAFT_04936 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: Glutamine amidotransferases class-II. | 0.826 |
EIC19417.1 | EIC20686.1 | Thi970DRAFT_04937 | Thi970DRAFT_04340 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hypothetical protein; PFAM: Formylglycine-generating sulfatase enzyme; PEGA domain. | 0.416 |
EIC19417.1 | EIC20695.1 | Thi970DRAFT_04937 | Thi970DRAFT_04350 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hypothetical protein; PFAM: Formylglycine-generating sulfatase enzyme; PEGA domain. | 0.416 |
EIC19417.1 | glyA | Thi970DRAFT_04937 | Thi970DRAFT_04939 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.742 |
EIC19417.1 | nrdR | Thi970DRAFT_04937 | Thi970DRAFT_04938 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.954 |
EIC20227.1 | EIC19416.1 | Thi970DRAFT_03851 | Thi970DRAFT_04936 | Selenocysteine lyase; PFAM: Aminotransferase class-V. | PFAM: Glutamine amidotransferases class-II. | 0.711 |
EIC20227.1 | EIC23051.1 | Thi970DRAFT_03851 | Thi970DRAFT_00702 | Selenocysteine lyase; PFAM: Aminotransferase class-V. | Putative methyltransferase; PFAM: Uncharacterized conserved protein (DUF2260); TIGRFAM: probable methyltransferase. | 0.552 |
EIC20227.1 | glyA | Thi970DRAFT_03851 | Thi970DRAFT_04939 | Selenocysteine lyase; PFAM: Aminotransferase class-V. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.649 |
EIC20686.1 | EIC19416.1 | Thi970DRAFT_04340 | Thi970DRAFT_04936 | Hypothetical protein; PFAM: Formylglycine-generating sulfatase enzyme; PEGA domain. | PFAM: Glutamine amidotransferases class-II. | 0.534 |
EIC20686.1 | EIC19417.1 | Thi970DRAFT_04340 | Thi970DRAFT_04937 | Hypothetical protein; PFAM: Formylglycine-generating sulfatase enzyme; PEGA domain. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.416 |