STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptpAThe low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatases) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate; Belongs to the Tyrosine-specific protein phosphatases family; Localized in the cytoplasm; High confidence in function and specificity. (148 aa)    
Predicted Functional Partners:
dnaA
Chromosomal replication initiator protein, DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
    
 0.934
CAZ94075.1
Methyltransferases; Enzyme that uses S-AdoMet in the methylation of diverse substrates; Belongs to the UPF0011 family; Localized in the cytoplasm; Specificity unclear.
     0.930
capC
Tyrosine-protein phosphatase; Dephosphorylates the phosphotyrosine-containing proteins required for the biosynthesis of type 1 capsular polysaccharide; Involved in the capsular polysaccharide (CPS) biosynthesis; Uses the mamganese as cofactor; Contains a polymerase and histidinol Phosphatase domain (PHP domain; Localized in the cytoplasm; High confidence in function and specificity.
     
 0.907
CAZ96747.1
Metallo-beta-lactamase superfamily protein; Protein with a N-terminal metallo beta-lactamase domain and two rhodanese (thiosulfate sulfurtransferase) domains: one where the active-site Cysteine residue is replaced by another aminoacid whereas the C-terminal domain displays the catalytic cysteine residue; binds two zinc ions per molecule as cofactor; Localized in the cytoplasm; Function unclear.
  
 
 0.844
CAZ94370.1
Conserved protein with a N-terminal domain belonging to the metallo-beta-lactamase superfamily and two rhodanese (thiosulfate sulfurtransferase) domains: one where the active-site cysteine residue is replaced by another aminoacid whereas the C-terminal domain displays the catalytic cysteine residue. contains various metallo-hydrolases including beta-lactamases, but also glyoxylases and arylsulfatases. The active site is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions; Localized in the cytoplasm; Function unclear.
  
 
 0.844
CAZ98563.1
Protein with a N-terminal domain belonging to the metallo-beta-lactamase superfamily and two rhodanese (thiosulfate sulfurtransferase) domains: one where the active-site cysteine residue is replaced by another aminoacid whereas the C-terminal domain displays the catalytic cysteine residue. The active site of the metallo-beta-lactamase domain is characterized by several conserved histidines binding the catalytic zinc ions. The enzymes can bind one or two zinc ions; Localized in the cytoplasm; Function unclear.
  
 
 0.844
kdsB
The 3-Deoxy-manno-octulosonate cytidylyltransferase, also known as CMP-KDO synthetase, activates KDO (a 8-carbon sugar) required for incorporation into bacterial lipopolysaccharide in Gram- negative bacteria; It binds one magnesium ion as cofactor; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the KdsB family.
    
 0.634
CAZ95741.1
Fructosamine kinase is responsible for the removal of fructosamines from proteins, by a sugar phosphorylation mechanism; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.590
CAZ94457.1
Type I polyketide synthases are modular enzymes involved in the synthesis of various polyketides. This enzyme encompasses five modules: beta-ketoacyl synthase (KS), acyltransferase (AC), dehydratase (DH), enoyl reductase (ER) and acyl carrier protein (ACP). This modular enzyme is homologous to mycocerosic acid synthase (EC 2.3.1.111). Binds 1 phosphopantetheine group covalently. Localized in the cytoplasmic membrane; Specificity unclear.
  
 
 0.550
etkA
Tyrosine-protein kinase; May be involved in the production and the transport of exopolysaccharides; Contains a N-terminal transmembrane segment; Belongs to the etk/wzc family; Localized in the cytoplasmic membrane; Specificity unclear.
  
 
 0.532
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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