STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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Experiments
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[Homology]
Score
argHArgininosuccinate lyase is involved in the eighth and last step of the arginine biosynthesis pathway. It converts the Omega-N-(L-arginino)succinate to fumarate and L-arginine; Belongs to the fumarate lyase family. Localized in the cytoplasm; High confidence in function and specificity. (426 aa)    
Predicted Functional Partners:
argG
Argininosuccinate synthase (AS) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate; Belongs to the argininosuccinate synthase family, type 1 subfamily; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.998
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
  
 0.988
argF
N-acetylornithine carbamoyltransferase catalyzes the convertion of N-acetylornithine to N-acetylcitrulline and has no catalytic activity with L-ornithine as substrate. ArgF' does not feature the SMG motif which is conserved in the canonical ArgF (L-ornithine to L- citrulline). In this alternative pathway, N-acetyl-L- citrulline is likely deacetylated by ArgE; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.987
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.977
argD
Acetylornithine aminotransferase catalyzes the transfer of an amino group from acetylornithine to alpha-ketoglutarate, yielding N-acetyl-glutamic-5-semi-aldehyde and glutamic acid. This is the fourth step in the arginine biosynthesis pathway. ArgD is also involved in the urea cycle. This enzyme uses the pyridoxal phosphate as cofactor linked to a conserved lysine residue. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.958
argE
Acetylornithine deacetylase, family M20A; Acetylornithine deacetylase catalyzes the fifth step of the arginine biosynthesis pathway, converting the 2-N-acetyl-L-ornithine to L-ornithine and acetate. L-ornithine is also a branchpoint in the synthesis of polyamines. ArgE binds two zinc ions per monomer of protein; Belongs to the family M20A of the metallopeptidases; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.935
purB
Adenylosuccinate lyase catalyzes step 8 in the pathway for de novo synthesis of IMP and also the final reaction in the two-step sequence from IMP to AMP. It cleaves succinylaminoimidazole carboxamide ribotide into aminoimidazole carboxamide ribotide and fumarate, as well as adenylosuccinate into adenylate and fumarate. Localized in the cytoplasm; High confidence in function and specificity.
    
 0.920
CAZ95283.1
The N-Acetyltransferases catalyze the transfer of an acetyl group from acetyl-CoA to a substrate molecule. Belongs to Gcn5 or GNAT actyltransferase family. Localized in the cytoplasm; Family membership.
 
  
 0.859
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.844
gltA
The citrate synthase is the enzyme that catalyzes an important reaction in both energy generation and carbon assimilation, the synthesis of citrate from oxaloacetate and acetyl-CoA in an aldol condensation, that is the first reaction of the tricarboxylic acid cycle (Krebs' cycle). It can directly form a carbon-carbon bond in the absence of metal ion cofactors; Allosterically inhibited by NADH; Localized in the cytoplasm; High confidence in function and specificity.
    
 0.837
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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