STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvdAMevalonate diphosphate decarboxylase or diphosphomevalonate decarboxylase catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP), the last step in the synthesis of IPP in the mevalonate pathway. Mevalonate is a key intermediate in the biosynthesis of sterols and non-sterol isoprenes; Belongs to the GHMP kinase domain superfamily; Localized in the cytoplasm; High confidence in function and specificity. (361 aa)    
Predicted Functional Partners:
idiA
Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.977
mvkA
Mevalonate kinase catalyses the phosphorylation of mevalonate to phosphomevalonate from AT as donor; Uses the magnesium ions as cofactor; CTP, GTP and UTP can also act as donors; Belongs to the GHMP kinase family; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.970
CAZ94094.1
Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.
  
 
 0.948
CAZ95249.1
Protein that is probably a kinase; belongs to the GHMP (galacto, homoserine, mevalonate, phosphomevalonate) kinase family; Localized in the cytoplasm; Family membership.
 
  
 0.942
idsA
Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]
  
 0.936
mvaA
3-Hydroxy-3-methylglutaryl-coenzyme A reductase catalyzes the reversible conversion of mevalonate into 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA), using coenzyme A and NAD(P) as cofactors. In Archeae, NADP-depedent HMG-CoA reductase is involved in the biosynthesis of the isoprenoids side chains of lipids. Some bacteria, such as Pseudomonas mevalonii, use an NAD-dependent HMG-CoA reductase to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. These bacteria can use mevalonate as sole carbon source. Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.859
CAZ97869.1
Conserved hypothetical periplasmic protein; Contains a signal peptide cleaved between the residues 21 and 22; Localized in the periplasmic space; Conserved hypothetical protein.
   
 
 0.706
gldN
Protein putatively involved in the gliding motility; Signal peptide cleaved between the residues 23 and 24; Localized in the periplasmic space; Function unclear.
  
     0.596
crtK
Protein possibly involved in the carotenoid biosynthesis; Contains five transmembrane segments; Belongs to the TspO/BZRP family; Localized in the cytoplasmic membrane; Function unclear.
       0.586
CAZ94756.1
Conserved hypothetical protein; Localized in the cytoplasm.
  
     0.529
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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