STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
CAZ95389.1The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain; Contains two transmembrane segments; Localized in the cytoplasmic membrane; Family membership. (384 aa)    
Predicted Functional Partners:
CAZ98664.1
The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains, an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor, and a variable C-terminal effector domain, here a PglZ domain, a member of Alkaline phosphatase clan; Localized in the cytoplasm; Family membership.
 
 
 
 0.805
CAZ94955.1
Conserved hypothetical periplasmic protein; Contains a signal peptide cleaved between the residues 18 and 19; Localized in the periplasmic space; Conserved hypothetical protein.
 
   
 0.764
bkdA1
2-Oxoisovalerate dehydrogenase, E1 component; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It is involved in valine, leucine and isoleucine biodegradation. This complex contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 component displays a modular architecture. The N-terminal domain is a dehydrogenase and the C-terminal domain belongs to the transketolase family. Both activities [...]
   
 0.658
bkdA2
2-Oxoisovalerate dehydrogenase, E1 component; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It is involved in valine, leucine and isoleucine biodegradation. This complex contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 component displays a modular architecture. The N-terminal domain is a dehydrogenase and the C-terminal domain belongs to the transketolase family. Both activities [...]
   
 0.658
CAZ95388.1
The flavoredoxins are a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential producing reduced flavin for various biological processes; Some flavin reductases function in a two-component enzyme system; Contains a FMN-binding split barrel; Specificity unclear.
 
    0.651
CAZ96609.1
Protein belonging to the skp family; Skp (OmpH) is a homotrimeric periplasmic chaperone for newly synthesised outer membrane proteins as they emerge in the periplasm from the Sec translocation machinery; Signal peptide cleaved between the residues 22 and 23; Localized in the periplasmic space; Family membership.
  
     0.647
CAZ95390.1
Hypothetical membrane protein; Contains a C-terminal transmembrane segment; Probably localized in the cytoplasmic membrane; Hypothetical protein.
       0.627
CAZ98287.1
This protein is a isolated response regulator receiver which is phosphorytaled by an histidine protein kinase environmental sensor. Belongs to the CheY family. Localized in the cytoplasm; Specificity unclear.
  
   0.606
sprA-2
Conserved hypothetical periplasmic protein; Signal peptide cleaved between the resedues 31 and 32; Localized in the periplasmic space; Conserved hypothetical protein.
 
  
 0.601
CAZ95351.1
The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. These proteins consist of two domains, an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor, and a variable C-terminal effector domain with DNA-binding activity (here, a winged-helix DNA-binding domain) that acts as transcriptional regulator; Family membership.
  
   0.596
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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