STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ95475.1TonB-dependent Receptor; Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations; Contains the Plug module (43-152) acting as a channel gate; The signal peptide is cleaved between the residues 19 and 20; Family membership. (693 aa)    
Predicted Functional Partners:
CAZ98306.1
Amidase catalyzes the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. The specificity of this enzyme is unknown. Belongs to a protein family including N-acetylmuramoyl-L-alanine amidase. Features an uncleaved signal peptide. Localized in the cytoplasmic membrane; Specificity unclear.
  
     0.596
xthA2
The exonuclease III catalyses the cleavage in the 3'- to 5'-direction on double-stranded DNA to yield nucleoside 5'-phosphates. It also has an endonucleolytic activity near apurinic sites on DNA; Contains an Endonuclease/Exonuclease/phosphatase domains; Belongs to the DNA repair enzymes AP family 1; Localized in the cytoplasm; High confidence in function and specificity.
       0.549
CAZ94220.1
TonB-dependent Receptor; Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations; Contains a carboxypeptidase regulatory domain (20-93) and the Plug module (110-246) acting as a channel gate; The signal peptide is cleaved between the residues 19 and 20; Family membership.
  
  
 0.530
tonB2
TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 
 0.428
CAZ94219.1
SusD/RagB family lipoprotein; Protein probably involved in nutrient binding and belonging to the SusD/RagB family; Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer; Contains a lipoprotein signal peptide cleaved between the residues 17 and 18; Probably localized in the outer membrane; Family membership.
  
     0.423
CAZ98307.1
Peptidase family M14 contains mainly metallocarboxypeptidases. The single catalytic zinc ion is tetrahedrally coordinated by two histidines and a glutamate, as well as a water molecule. One of the histidines and the glutamate occur in the motif His-Xaa-Xaa-Glu. Features a signal peptide cleaved between the residues 18 and 19. Localized in the periplasm; Specificity unclear.
  
     0.407
tonB1
TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 
 0.401
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.