STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
CAZ95688.1cAMP-binding dependent transcriptionnal regulator; This protein complexes with cAMP via an N-terminal cyclic nucleotide-binding domain and binds to specific DNA sites, via a C-terminal crp-type HTH domain, near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA; Family membership. (251 aa)    
Predicted Functional Partners:
CAZ95689.1
Nitrate/nitrite-specific MFS transporter protein; Putatively involved in the uptake of nitrate or extrusion of nitrite; The proteins contains 12 transmembrane segments; Localized in the cytoplasmic membrane; Function unclear.
 
  
 0.801
CAZ95683.1
Conserved hypothetical periplasmic protein; Contains a signal peptide cleaved between the residues 20 and 21; Localized in the periplasmic space; Conserved hypothetical protein.
 
     0.491
nrtB
Nitrate-specific BPD transport, permease component; Probably part of a high-affinity binding-protein-dependent (BPD) transport system for nitrate; probably responsible for the translocation of the substrate across the membrane; Localized in the cytoplasmic membrane by six transmembrane segments; High confidence in function and specificity.
 
     0.480
narB/nirB
Respiratory nitrate/nitrite reductase; Bifunctional enzyme involved in the denitrification processes (nitrate respiration). It contains in its N-terminal part a nitrate reductase module required for nitrate assimilation (reducing nitrate to nitrite) using molybdopterin and 1 4Fe-4S cluster as cofactors and in its C-terminal part a nitrite reductase module required for nitrite assimilation (reducing nitrite to ammonia) using FAD, 4Fe-4S cluster and siroheme as cofactors; Belongs to Belongs to the prokaryotic molybdopterin-containing oxidoreductase family and to the nitrite and sulfite r [...]
 
  
 0.476
ccoNO
Fusion of the subunits CcoN and CcoO of the Cytochrome cbb3 oxidase. Converts the ferrocytochrome to ferricytochrome. Belongs to the ccoNOQP operon. Contains 13 transmembrane helices; Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
  
 0.459
nrtA
Essential component of the nitrate-transporting system. May be the substrate-binding protein; Lipoprotein putatively anchored in the outer membrane or in the cytoplasmic membrane (or in both membranes) by its N-terminal lipidic residue (peripheral membrane protein); High confidence in function and specificity.
     
 0.442
ccoI
Belongs to the cation transport P-type ATPase family. Involved in the ccoGHIS operon. Features eight transmembrane helices. Localized in the cytoplasmic membrane; Hypothetical protein.
 
   
 0.433
nrtD
Nitrate-specific ABC transporter, ATPase component; This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane); Probably part of a high-affinity binding-protein-dependent transport system for nitrate. Probably responsible for energy coupling to the transport system; Family membership.
 
   
 0.432
cobA2
Uroporphyrin-III C-methyltransferase; This enzyme catalyzes two sequential methylation reactions, forming precorrin-1 and precorrin-2 by methylations at C-2 and C-7 of uroporphyrinogen III respectively; It is the first enzyme specific to the cobalamin (vitamin B12) pathway and precorrin-2 is a common intermediate in the biosynthesis of corrinoids such as vitamin B12, siroheme and coenzyme F430; Belongs to the precorrin methyltransferase family; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.429
nrtC
Nitrate-specific ABC transporter, ATPase component; This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase) encoded by a different gene of those that encode for the ABC transporter permease component (ABC membrane); Probably part of a high-affinity binding-protein-dependent transport system for nitrate. Probably responsible for energy coupling to the transport system; Family membership.
 
   
 0.421
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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