STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vacBRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (731 aa)    
Predicted Functional Partners:
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
    
 0.778
CAZ94207.1
Nucleoside diphosphate pyrophosphatase; This family of proteins catalyses the hydrolysis of phosphorus-containing acid anhydrides such as nucleoside diphosphate, for example ADP-mannose and UDP-glucose; Protein that consists of a NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) domain; Localized in the cytoplasm; Family membership.
   
 0.722
CAZ94607.1
NUDIX hydrolase belongs to a family of enzymes hydrolyzing diverse nucleoside diphosphate derivatives (including ADP-ribose, GDP- mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP). Localized in the cytoplasm; Function unclear.
   
 0.722
CAZ94754.1
NUDIX hydrolase; This conserved protein belongs to the Nudix (NUcleoside DIphosphate linked to some other moiety X) hydrolase family. Its specificity is unclear; Localized in the cytoplasm; Family membership.
   
 0.722
gltX
Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
 
 
 0.716
rplV
Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
 
 
 0.683
CAZ96589.1
tRNA/rRNA methyltransferase; Catalyzes the site-specific methylation of the 2' hydroxy group of the ribose in rRNA or tRNA, using the S-AdoMet; Contains a N-terminal RNA 2'-O ribose methyltransferase substrate binding domain and a C-terminal catalytic domain also involved in the dimer formation that adopts an alpha/beta knot fold; Belongs to the RNA methyltransferase TrmH family; Localized in the cytoplasm; Family membership.
 
 
 0.667
rlmB
23S rRNA (guanosine-2'-O-)-methyltransferase; RmlB specifically methylates the 2' hydroxy group of the ribose of guanosine 2251 in 23S rRNA, using the S-AdoMet; Contains a N-terminal RNA 2'-O ribose methyltransferase substrate binding domain and a C-terminal catalytic domain also involved in the dimer formation that adopts an alpha/beta knot fold; Belongs to the RNA methyltransferase TrmH family; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.655
rplX
Ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
  
 0.638
trmH
tRNA guanosine-2'-O-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
 
 
 0.636
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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