STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rmlCdTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa)    
Predicted Functional Partners:
rmlB
dTDP-glucose 4,6-dehydratase converts the dTDP-glucose to dTDP-4-dehydro-6-deoxy-D-glucose. This enzyme is involved in the nucleotide sugar metabolism and in the lipopolysaccharide biosynthesis; Belongs to the NAD dependent epimerase/dehydratase family, Rossmann fold Superfamily; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.999
rmlD
dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
 
 0.999
rmlA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
 0.998
CAZ97918.1
UDP-glucuronic acid decarboxylase converts the UDP-D-glucuronic acid to UDP-D-xylose and CO2. This enzyme is involved in the nucleotide sugar metabolism; Belongs to the NAD dependent epimerase/dehydratase family, Rossmann fold Superfamily; Localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.938
CAZ94548.1
RmlD substrate binding domain family protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
  
 
 0.878
wzxA
O-antigen translocase; WzxA translocates undecaprenylpyrophosphate-bound O-antigen subunits from the cytoplasm to the periplasm. Wzx is an integral membrane protein involved in lipopolysaccharide biosynthesis; Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
  
 0.864
galF
UTP--glucose-1-phosphate uridylyltransferase; Enzyme involved in Lipopolysaccharide O antigen biosynthesis. It biosynthetizes UDP-glucose from uridine triphosphate and glucose 1-phosphate; Belongs to the UDPGP type 2 family; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.824
CAZ98633.1
Glycosyl transferase, family GT 2; Glycosyl transferase possibly involved in the cell wall biosynthesis; Belongs to the family 2 of glycosyl transferases (GT2); Localized in the cytoplasm; Family membership.
 
  
 0.793
algD
GDP-mannose 6-dehydrogenase catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid. In Pseudomonas aeruginosa, this activated sugar is the precursor for alginate polymerization. AlgD belongs to the UDP-glucose/GDP- mannose dehydrogenase family, a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate. Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.769
ugdH
UDP-glucose 6-dehydrogenase catalyzes the oxidation of UDP-glucose to UDP-glucuronate. Likely involves in EPS biosynthesis. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family, a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.769
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.