STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ95842.1Oxydoreductase NADPH dependent; Belongs to the aldo/keto reductase 1 family; Localized in the cytoplasm; Family membership. (280 aa)    
Predicted Functional Partners:
CAZ98364.1
Contains an Iron-containing alcohol dehydrogenase domain; Belongs to the iron-containing alcohol dehydrogenase family; Localized in the cytoplasm; Family membership.
  
 
 0.925
CAZ95591.1
Protein belonging to the Glyoxalase superfamily; Localized in the cytoplasm; Family membership.
   
 0.921
CAZ98106.1
Glyoxalase superfamily protein; Contains a signal peptide cleaved between the residues 20 and 21; Belongs to the Glyoxalase superfamily; Localized in the periplasmic space; Family membership.
   
 0.921
aldA-3
Lactaldehyde dehydrogenase is involved in the catabolism of L-fucose and L-rhamnose and is induced by these sugars. AldA catalyzes the NAD-dependent oxidation of lactaldehyde into lactate; Forms a tetramer; Belongs to the aldehyde dehydrogenase fold family; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.915
ghrA
Glyoxylate/hydroxypyruvate reductase A catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively; Contains a glycine-rich region located in the central section corresponding to the NAD-binding domain; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
    
 0.910
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.815
CAZ95265.1
FAD-dependent amine oxidoreductase of unknown substrate specificity; Belongs to the amine oxydase family; Localized in the cytoplasm; Specificity unclear.
   
 
 0.808
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
    
  0.804
otsAB
Trehalose-6-phosphate synthase/phosphatase, family GT20; This enzyme is involved in the biosynthesis of trehalose. It is a fusion protein between the trehalose-6-phosphate synthase (OtsA) and the trehalose-6-phosphate phosphatase (OtsB). Trehalose-6-phosphate synthase catalyzes the reaction: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate. It belongs to the family 20 of the glycosyltransferases (GT20). trehalose-6-phosphate phosphatase catalyzes the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate. Localized in the cytoplasm; High confidence i [...]
   
  
 0.800
sdaA1
L-serine dehydratase is involved in the gluconeogenesis pathway. It catalyzes the deamination of serine to form pyruvate. It is activated by a post-translational modification via a system involving at least three gene products. There is considerable evidence for a free-radical activation mechanism; Binds a 4Fe-4S cluster as a cofactor; Localized in the cytoplasm; High confidence in function and specificity.
     
  0.800
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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