STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (335 aa)    
Predicted Functional Partners:
polA
DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.991
uvrD
DNA helicase unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Contains a uvrD-like helicase ATP-binding domain and a uvrD-like helicase C-terminal domain; Belongs to the helicase family, UvrD subfamily Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.882
recX
RecX-type transcriptional regulator; Modulates RecA activity; Belongs to the RecX family.
  
 
 0.881
CAZ97558.1
Conserved hypothetical protein; Localized in the cytoplasm.
  
 
 0.863
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 0.843
recQ1
RecQ is a ATP-dependent DNA helicase involved in genome maintenance in the RecF recombination pathway; RecQ unwinds paired DNA, translocating in a 3' to 5' direction; The expression of RecQ gene is under the regulation of the SOS system. Contains a DEAD/H box and a HRDC domain; Belongs to superfamily II of helicases, RecQ family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.837
recQ2
RecQ is a ATP-dependent DNA helicase involved in genome maintenance in the RecF recombination pathway; RecQ unwinds paired DNA, translocating in a 3' to 5' direction; The expression of RecQ gene is under the regulation of the SOS system. Contains a DEAD/H box and a HRDC domain; Belongs to superfamily II of helicases, RecQ family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.837
CAZ98100.1
The ATP-dependent DNA helicases are involved in unwinding of DNA; Contains a DEAD/H dopmain involved in the ATP binding and a Helicase conserved C-terminal domain; Belongs to superfamily II of helicases; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.837
topA1
DNA topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...]
  
 0.811
radA
DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
   
  
 0.800
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: medium (58%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.