STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
idnO1Gluconate-5-dehydrogenase; Also called 5-keto-D-gluconate 5-reductase; Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate using NADP as a coenzyme. Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Localized in the cytoplasm; High confidence in function and specificity. (266 aa)    
Predicted Functional Partners:
kduI1
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.
  
 0.814
CAZ94263.1
This protein belongs to the family 105 of the glycoside hydrolases. These enzymes are involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. Asp104 is the putative catalytic residue (identical to Asp143 of the unsaturated rhamnogalacturonyl hydrolase from Bacillus subtilis, Itoh et al., 2006, BBRC 347, 10211029). Features a signal peptide cleaved between residues 20 and 21. Localized in the periplasm; Specificity unclear.
       0.775
CAZ94260.1
The Sugar permeases belong to the major facilitator superfamily (MFS) transporters that are single-polypeptide secondary carriers capable only of transporting small solutes (probably sugars in this case) in response to chemiosmotic ion gradients; Contains 11 transmembrane segments; Localized in the cytoplasmic membrane; Family membership.
  
    0.711
mdmC
MdmC is a 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 
 0.641
CAZ94259.1
Conserved hypothetical membrane protein; Contains a putaive lipoprotein signal peptide cleaved between the residues 18 and 19; Possibly localized in the outer membrane; Conserved hypothetical protein.
       0.548
gntK2
Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate; GntK adopts an alpha/beta fold, consisting of a central sheet of five parallel beta-strands flanked by alpha-helices; Belongs to the shikimate kinase family; Localized in the cytoplasm; High confidence in function and specificity.
   
 0.508
CAZ94457.1
Type I polyketide synthases are modular enzymes involved in the synthesis of various polyketides. This enzyme encompasses five modules: beta-ketoacyl synthase (KS), acyltransferase (AC), dehydratase (DH), enoyl reductase (ER) and acyl carrier protein (ACP). This modular enzyme is homologous to mycocerosic acid synthase (EC 2.3.1.111). Binds 1 phosphopantetheine group covalently. Localized in the cytoplasmic membrane; Specificity unclear.
 
 
 0.507
CAZ94264.1
SusD/RagB family lipoprotein; Protein probably involved in nutrient binding and belonging to the SusD/RagB family; Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer; Contains a lipoprotein signal peptide cleaved between the residues 18 and 19; Probably localized in the cytoplasmic membrane; Family membership.
       0.490
CAZ94265.1
TonB-dependent Receptor; Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations; Contains a carboxypeptidase regulatory domain (52-125) and the Plug module (141-255) acting as a channel gate; The signal peptide is cleaved between the residues 33 and 34; Family membership.
       0.487
fabD
Malonyl CoA-acyl carrier protein transacylase is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein; High confidence in function and specificity.
 
 
 0.470
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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