Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.

Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity.

Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.

Mevalonate diphosphate decarboxylase or diphosphomevalonate decarboxylase catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP), the last step in the synthesis of IPP in the mevalonate pathway. Mevalonate is a key intermediate in the biosynthesis of sterols and non-sterol isoprenes; Belongs to the GHMP kinase domain superfamily; Localized in the cytoplasm; High confidence in function and specificity.

Phosphomannomutase/phosphoglucomutase; AlgC catalyzes the interconversion between mannose-6-phosphate and alpha-mannose-1-phosphate. It has also a phosphoglucomutase activity interconverting glucose-6-phosphate and alpha-glucose-1-phosphate. Likely involved in EPS/LPS biosynthesis. Binds one magnesium as cofactor. Localized in the cytoplasm; High confidence in function and specificity.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

Phosphomannomutase/phosphoglucomutase; AlgC catalyzes the interconversion between mannose-6-phosphate and alpha-mannose-1-phosphate. It has also a phosphoglucomutase activity interconverting glucose-6-phosphate and alpha-glucose-1-phosphate. Likely involved in EPS/LPS biosynthesis. Binds one magnesium as cofactor. Localized in the cytoplasm; High confidence in function and specificity.

Octaprenyl diphosphate synthase supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones, ubiquinone and menaquinone; Localized in the cytoplasm; High confidence in function and specificity.

Phosphomannomutase/phosphoglucomutase; AlgC catalyzes the interconversion between mannose-6-phosphate and alpha-mannose-1-phosphate. It has also a phosphoglucomutase activity interconverting glucose-6-phosphate and alpha-glucose-1-phosphate. Likely involved in EPS/LPS biosynthesis. Binds one magnesium as cofactor. Localized in the cytoplasm; High confidence in function and specificity.

Methionyl-tRNA synthetase, class Ia; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

Phosphomannomutase/phosphoglucomutase; AlgC catalyzes the interconversion between mannose-6-phosphate and alpha-mannose-1-phosphate. It has also a phosphoglucomutase activity interconverting glucose-6-phosphate and alpha-glucose-1-phosphate. Likely involved in EPS/LPS biosynthesis. Binds one magnesium as cofactor. Localized in the cytoplasm; High confidence in function and specificity.

Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.

Cytidylate kinase is involved in pyrimidine nucleotide metabolism. It catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP. Localized in the cytoplasm; High confidence in function and specificity.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate, this intermediate is then rearranged to form phytoene; Belongs to the phytoene/squalene synthetase family; Localized in the cytoplasm; High confidence in function and specificity.

Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity.

The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate, this intermediate is then rearranged to form phytoene; Belongs to the phytoene/squalene synthetase family; Localized in the cytoplasm; High confidence in function and specificity.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate, this intermediate is then rearranged to form phytoene; Belongs to the phytoene/squalene synthetase family; Localized in the cytoplasm; High confidence in function and specificity.

Octaprenyl diphosphate synthase supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones, ubiquinone and menaquinone; Localized in the cytoplasm; High confidence in function and specificity.

The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate, this intermediate is then rearranged to form phytoene; Belongs to the phytoene/squalene synthetase family; Localized in the cytoplasm; High confidence in function and specificity.

Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.

Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity.

Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.

Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity.

The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate, this intermediate is then rearranged to form phytoene; Belongs to the phytoene/squalene synthetase family; Localized in the cytoplasm; High confidence in function and specificity.

Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

Isopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity.

Mevalonate diphosphate decarboxylase or diphosphomevalonate decarboxylase catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP), the last step in the synthesis of IPP in the mevalonate pathway. Mevalonate is a key intermediate in the biosynthesis of sterols and non-sterol isoprenes; Belongs to the GHMP kinase domain superfamily; Localized in the cytoplasm; High confidence in function and specificity.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

Phosphomannomutase/phosphoglucomutase; AlgC catalyzes the interconversion between mannose-6-phosphate and alpha-mannose-1-phosphate. It has also a phosphoglucomutase activity interconverting glucose-6-phosphate and alpha-glucose-1-phosphate. Likely involved in EPS/LPS biosynthesis. Binds one magnesium as cofactor. Localized in the cytoplasm; High confidence in function and specificity.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

Cytidylate kinase is involved in pyrimidine nucleotide metabolism. It catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP. Localized in the cytoplasm; High confidence in function and specificity.

Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]

The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate, this intermediate is then rearranged to form phytoene; Belongs to the phytoene/squalene synthetase family; Localized in the cytoplasm; High confidence in function and specificity.