STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CAZ96007.1Metal dependent transcriptional regulator binds two divalent metal effectors per monomer via an dimerization domain with two metal-binding sites, upon which allosteric changes occur that moderate binding to the cognate DNA operators of a target gene via a N-terminal DtxR-type HTH domain; Contains an C-terminal SH3-like domain that characterizes the Fe(II)-regulators. It may act to stabilizing the dimeric form of the repressor; Family membership. (218 aa)    
Predicted Functional Partners:
zupT
Heavy-metal cations permease; Mediates zinc uptake. May also transport other divalent cations; Contains three N-terminal and three C-terminal transmembrane segments; Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
  
 0.848
CAZ96006.1
TonB-dependent Receptor; Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations; Contains a carboxypeptidase regulatory domain (26-104) and the Plug module (121-228) acting as a channel gate; The signal peptide is cleaved between the residues 23 and 24; Putatively involved in the colicin 1A and 1B uptake; Family membership.
 
     0.626
nadR
Nicotinamide-nucleotide adenylyltransferase / Ribosylnicotinamide kinase; Bifunctional enzyme involved in the nicotinate and nicotinamide metabolism possessing both NMN (nicotinamide mononucleotide) adenylytransferase (NMNAT) and Ribosylnicotinamide kinase (RNK) activities. NMNAT is an indispensable activity in the biosynthesis of NAD(+) and NADP(+) synthesizing NAD via the salvage pathway. RNK converts the N-ribosylnicotinamide to nicotinamide ribonucleotide; Localized in the cytoplasm. However, this bifunctional enzyme would loosely associate with the membrane through its interaction [...]
   
    0.517
sodA
Superoxide dismutase [Mn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
 
   
 0.508
CAZ96969.1
Conserved protein belonging to the NAD(P)-dependent epimerase/dehydratase family. Adopts a Rossmann fold. Localized in the cytoplasm; Function unclear.
   
    0.499
tpx
Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily.
  
  
 0.481
CAZ97328.1
Transcriptional regulator featuring a helix-turn-helix DNA binding motif belonging to the Fur family. This family includes metal ion uptake regulator, that bind to the operator DNA and controls transcription of metal ion-responsive genes. Localized in the cytoplasm; Specificity unclear.
  
  
 0.471
furA1
Ferric uptake regulation protein is a transcriptional regulator that acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed metal ion-responsive genes. It regulates the expression of several outer- membrane proteins including the iron transport operon; Contains a N-terminal Fur-type HTH DNA-binding domain; Belongs to the Fur family; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.471
furA2
Ferric uptake regulation protein is a transcriptional regulator that acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed metal ion-responsive genes. It regulates the expression of several outer- membrane proteins including the iron transport operon; Belongs to the Fur family; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.471
CAZ98502.1
Transcriptional regulator belonging to the Ferric uptake regulator or FUR family, which includes metal ion uptake regulator proteins, which bind to the operator DNA and control the transcription of metal ion-responsive genes. Localized in the cytoplasm; Family membership.
  
  
 0.471
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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