STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fabB53-oxoacyl-[acyl-carrier-protein] synthase, also known as beta-ketoacyl synthase, catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids; Belongs to the Beta-ketoacyl synthase family; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (405 aa)    
Predicted Functional Partners:
fabD
Malonyl CoA-acyl carrier protein transacylase is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein; High confidence in function and specificity.
 0.998
fabG2
3-oxoacyl-[acyl-carrier protein] reductase; FabG catalyzes the first reduction step of the fatty acid biosynthesis pathway. Belongs to the short- chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Localized in the cytoplasm; High confidence in function and specificity.
  0.995
darB
DarB is homologous to 3-oxoacyl-[acyl-carrier-protein] synthase III, also known as beta-ketoacyl-ACP synthase III (FabH), which catalyses the first condensation step within the fatty acid synthesis pathway converting the Acyl-[acyl-carrier-protein] to 3-oxoacyl-[acyl-carrier-protein]; Localized in the cytoplasm; Specificity unclear.
 
 
 0.985
fabH2
3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 0.974
fabF
3-oxoacyl-[acyl-carrier-protein] synthase II, also known as beta-ketoacyl synthase II, catalyzes the condensation reaction of fatty acid synthesis by the addition of two carbons from malonyl-ACP to an acyl acceptor. FabF Has a preference for short chain acid substrates; Belongs to the Beta-ketoacyl synthase family; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
  0.973
fabH1
3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 0.970
acpP3
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
 
 
 0.963
fabI
Enoyl-[acyl-carrier-protein] reductase (NADH); FabI is a NADH-dependent enoyl-ACP reductase and is involved in fatty acid biosynthesis. It catalyzes the reaction : Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH. It forms a homotetramer and binds A NAD+ per subunit. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.963
fabG1
3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  0.960
fabH3
3-oxoacyl-[acyl-carrier-protein] synthase III, also known as beta-ketoacyl-ACP synthase III, catalyses the reaction: Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. This is the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain. Negatively regulated by acyl-ACP, possibly by binding to either the free [...]
 
 
 0.957
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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