STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ggcXVitamin K-dependent gamma-glutamyl carboxylase is involved in the Vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues in various proteins. It converts glutamate residues to gamma-carboxyglutamate; Contains six transmembrane helices; Localized in the cytoplasmic membrane; High confidence in function and specificity. (446 aa)    
Predicted Functional Partners:
wrbA
NAD(P)H dehydrogenase [quinone]; The enzyme catalyse the NAD(P)H-dependent two-electron reductions of quinones; It apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons to protect cells against damage by free radicals and reactive oxygen species; It has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone; Uses a FAD cofactor; Localized in the cytoplasm; High confidence in function and specificity.
    
  0.901
menG/ubiE
Menaquinone/ubiquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
     
 0.901
ytfG
YtfG belongs to the NmrA-type oxidoreductase family, but its exact function is unknown; Localized in the cytoplasm; Family membership.
     
  0.900
CAZ98775.1
NmrA family oxidoreductase; Conserved protein belonging to the NmrA-type oxidoreductase family, but its exact function is unknown. NmrA is a negative transcriptional regulator involved in the control of nitrogen metabolite repression in various fungi. Its crystal structure has revealed an unexpected similarity to the short-chain dehydrogenase/reductase (SDR) family. NAD binds to NmrA in vitro. Localized in the cytoplasm; Family membership.
     
  0.900
ribF
Riboflavin biosynthesis protein RibF is a protein that includes a Riboflavin kinase activity and a FMN adenylyltransferase activity; Localized in the cytoplasm; High confidence in function and specificity.
       0.796
CAZ96295.1
Metalloendopeptidase, family M12; Endopeptidase Containing a large C-terminal region, encompassing a fibronectin type 3 domain and a proprotein convertase P-domain necessary for folding and maintaining the endopeptidase catalytic domain and to regulate its calcium and acidic pH dependence; Belongs to the family 12 of the metallopeptidases (M12); Signal peptide cleaved between the residues 22 and 23; Localized in the periplasmic space; Specificity unclear.
  
    0.581
CAZ96296.1
Protein that contains two type-III fibronectin (FN3) domains. Structures of individual FN3 domains have revealed a conserved beta sandwich fold also found in bacterial glycosyde hydrolases and other proteins; Contains a putative lipoprotein signal peptide cleaved between the residues 16 and 17; Possibly localized in the outer membrane; Function unclear.
       0.562
irpA1
Iron-regulated protein A; IrpA occurs under iron-deficient growth conditions and disappears in cells recovering from iron starvation. It seems to be involved in iron acquisition, uptake or storage; Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 26 and 25; Localized in the cytoplasmic and/or outer membrane; Function unclear.
 
     0.513
pfkB
6-Phosphofructokinase, isozyme 2; 6-Phosphofructokinase catalyzes the thirth step of glycolysis (Embden-Meyerhof pathway). It phosphoryles the D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. It is an allosteric homodimer enzyme. Because the reaction catalyzed by Phosphofructokinase is energetically very favorable, it is essentially irreversible; Belongs to the carbohydrate kinase PfkB family; Localized in the cytoplasm; High confidence in function and specificity.
   
    0.499
CAZ95321.1
Conserved hypothetical lipoprotein; Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 30 and 31; Localized in the outer membrane; Conserved hypothetical protein.
  
     0.465
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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