STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ96314.1Conserved protein with NHL repeats; Contains five NHL repeats involved in the formation of beta-propeller fold; Localized in the cytoplasm; Conserved hypothetical protein. (364 aa)    
Predicted Functional Partners:
CAZ96322.1
Conserved hypothetical protein; Localized in the cytoplasm.
 
 
   0.827
hyaD
Hydrogenase maturation protease, family A31; Endopeptidase involved in the maturation of the large subunit of a specific Ni-Fe hydrogenase. The Ni-Fe hydrogenases contain the metallo centre, and once nickel has been bound in this, the subunit is processed to the active enzyme by cleavage at a conserved site near the C-terminus; Belongs to the family 31 of the aspartic peptidases (A31); Localized in the cytoplasm; High confidence in function and specificity.
 
     0.817
hyaB
Ni-Fe hydrogenase, large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process; Forms a heterodimer; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.811
hyaA
Ni-Fe hydrogenase, large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process; Forms a heterodimer; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.808
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
     0.776
CAZ96313.1
Protein that transports nickel ions with High-affinity; Contains five transmembrane helices; Localized in the cytoplasmic membrane; Specificity unclear.
 
     0.641
hypE
HypE (or HupE) is a protein required for expression of catalytically active hydrogenase in many systems. It appears to be an accessory protein involved in maturation rather than a regulatory protein involved in expression. HypE would be part of the hyp operon (Ni-Fe hydrogenase); Localized in the cytoplasm; High confidence in function and specificity.
       0.626
CAZ96805.1
Conserved hypothetical protein; Contains an N-terminal PHP (Polymerase and Histidinol Phosphatase) domain which is a putative phosphoesterase domain and a putative C-terminal ABC (ATP-binding cassette) transporter, ABC ATPase domain; Could belong to the PHP superfamily; Localized in the cytoplasm.
  
     0.523
hypC
The hydrogenase expression/formation proteins HypC is a part of the operon (Ni-Fe hydrogenase). HypC is a hydrogenase precursor-specific chaperone required for a maturation process. They are believed to keep the hydrogenase precursor in a conformation accessible for metal incorporation in active site; Belongs to the hupF/hypC family; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.493
CAZ94992.1
Serine peptidase, family S8; Serine peptidase contains a catalytic triad in the order Asp, His and Ser in the sequence. Its structure consists of three layers with a seven-stranded beta sheet sandwiched between two layers of helices; Belongs to the family S8 of peptidases; Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18; Localized in the cytoplasmic membrane; Specificity unclear.
 
   0.416
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.