STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ96322.1Conserved hypothetical protein; Localized in the cytoplasm. (493 aa)    
Predicted Functional Partners:
hyaD
Hydrogenase maturation protease, family A31; Endopeptidase involved in the maturation of the large subunit of a specific Ni-Fe hydrogenase. The Ni-Fe hydrogenases contain the metallo centre, and once nickel has been bound in this, the subunit is processed to the active enzyme by cleavage at a conserved site near the C-terminus; Belongs to the family 31 of the aspartic peptidases (A31); Localized in the cytoplasm; High confidence in function and specificity.
 
     0.951
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.948
hyaB
Ni-Fe hydrogenase, large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process; Forms a heterodimer; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.900
hyaA
Ni-Fe hydrogenase, large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process; Forms a heterodimer; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.889
CAZ96314.1
Conserved protein with NHL repeats; Contains five NHL repeats involved in the formation of beta-propeller fold; Localized in the cytoplasm; Conserved hypothetical protein.
 
 
   0.827
CAZ96324.1
Hypothetical protein; Putatively localized in the cytoplasm.
       0.791
CAZ96323.1
Hypothetical protein; Putatively localized in the cytoplasm.
       0.773
CAZ96313.1
Protein that transports nickel ions with High-affinity; Contains five transmembrane helices; Localized in the cytoplasmic membrane; Specificity unclear.
 
     0.771
CAZ96268.1
Endonuclease/exonuclease/phosphatase family protein; Contains an OB-fold nucleic acid binding domain and an endonuclease/phosphatase domain; Signal peptide cleaved between the residues 19 and 20; Localized in the periplasmic space; Family membership.
  
     0.751
hypB
The hydrogenase accessory protein HypB is a part of the hyp operon (Ni-Fe hydrogenase). HypB is a GTP hydrolase for assembly of nickel metallocentre of hydrogenase. The GTP hydrolysis catalyzed is an integral process in the incorporation of nickel into hydrogenases; Belongs to the hypB/hupM family; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.697
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.