STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hyaDHydrogenase maturation protease, family A31; Endopeptidase involved in the maturation of the large subunit of a specific Ni-Fe hydrogenase. The Ni-Fe hydrogenases contain the metallo centre, and once nickel has been bound in this, the subunit is processed to the active enzyme by cleavage at a conserved site near the C-terminus; Belongs to the family 31 of the aspartic peptidases (A31); Localized in the cytoplasm; High confidence in function and specificity. (159 aa)    
Predicted Functional Partners:
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.959
hyaB
Ni-Fe hydrogenase, large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process; Forms a heterodimer; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.956
CAZ96322.1
Conserved hypothetical protein; Localized in the cytoplasm.
 
     0.951
hyaA
Ni-Fe hydrogenase, large subunit is one hydrogenase synthesized in response to different physiological conditions. Could be involved in the detoxcation process; Forms a heterodimer; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.931
CAZ96314.1
Conserved protein with NHL repeats; Contains five NHL repeats involved in the formation of beta-propeller fold; Localized in the cytoplasm; Conserved hypothetical protein.
 
     0.817
hypB
The hydrogenase accessory protein HypB is a part of the hyp operon (Ni-Fe hydrogenase). HypB is a GTP hydrolase for assembly of nickel metallocentre of hydrogenase. The GTP hydrolysis catalyzed is an integral process in the incorporation of nickel into hydrogenases; Belongs to the hypB/hupM family; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.812
CAZ96324.1
Hypothetical protein; Putatively localized in the cytoplasm.
       0.790
hypC
The hydrogenase expression/formation proteins HypC is a part of the operon (Ni-Fe hydrogenase). HypC is a hydrogenase precursor-specific chaperone required for a maturation process. They are believed to keep the hydrogenase precursor in a conformation accessible for metal incorporation in active site; Belongs to the hupF/hypC family; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.783
CAZ96323.1
Hypothetical protein; Putatively localized in the cytoplasm.
       0.773
hypF
Along with hypE, HypF functions as a carbamoyl transferase catalyzing the synthesis of CO and CN-ligands of the active site iron of [NiFe]-hydrogenases using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of hypE yielding a protein-S-carboxamide; Forms a complex with hypE; Contains an N-terminal acylphosphatase domain, two repeats of zinc fingers and a C-terminal O-carbamoyltransferase domain; Localized in the cytoplasm; High confidence in function and specificity.
 
   
 0.708
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.