STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
Score
gcdHGlutaryl-CoA dehydrogenase catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism; Uses FAD as prosthetic group; Belongs to the acyl-CoA dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity. (392 aa)    
Predicted Functional Partners:
etfA
Electron transfer flavoprotein, alpha subunit; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various dehydrogenases. In Bacteria, ETFs are produced under specific growth conditions, receiving electrons only from the oxidation of specific substrates. ETFs are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and an AMP molecule. EtfA codes the alpha subunit that participate, with the alpha subunit, to the binding of the FAD molecule; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.985
fadA
3-Ketoacyl-CoA thiolase, also known as acetyl-CoA C-acyltransferase, has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. It catalyzes the reaction: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. Localized in the cytoplasm; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.958
fadN
3-Hydroxyl-CoA dehydrogenase / Enoyl-CoA hydratase; Modular protein containing a N-terminal 3-Hydroxyl-CoA dehydrogenase domain and a C-terminal Enoyl-CoA hydratase domain. In Bacillus subtilis, this protein was formerly known as YusL, and has been renamed FadN by Matsuoka et al (JBC, 2007). FadN is involved in fatty acid degradation. 3-Hydroxyl-CoA dehydrogenase catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. It uses NAD as cofactor. Enoyl-CoA hydratase catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA. Localized in the cytoplasm; High confidence in [...]
 
 0.930
etfB
Electron transfer flavoprotein, beta subunit; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various dehydrogenases. In Bacteria, ETFs are produced under specific growth conditions, receiving electrons only from the oxidation of specific substrates. ETFs are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and an AMP molecule. EtfB codes the beta subunit that binds the AMP molecule; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.928
CAZ94724.1
Acyl-CoA dehydrogenases catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD. Reoxidation of the flavin involves transfer of electrons to ETF (electron transfering flavoprotein). These enzymes are homodimers containing one molecule of FAD; Localized in the cytoplasm; Specificity unclear.
  
  
 
0.924
hbdA
The 3-Hydroxybutyryl-CoA dehydrogenase is involved in butyrate/butanol-producing pathway. It converts the (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.922
paaF
The enoyl-CoA hydratase (ECH) is an enzyme involved in fatty acid metabolism. It catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA; High confidence in function and specificity.
 
 0.915
sucB
Dihydrolipoamide succinyltransferase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
   
 0.911
bfmBAB
Dihydrolipoyllysine-residue (2-methylpropanoyl) transferase, E2 component; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO2. It is involved in valine, leucine and isoleucine biodegradation. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). This protein is the E2 component and catalyzes the reaction: 2-methylpropanoyl-CoA + enzyme 6-N-(dihydrolipoyl)lysine = CoA + enzyme 6-N-(S-(2-methylpr [...]
   
 0.911
acxA
Acyl-coA oxidase, with FAD cofactor, converts acyl-CoA into trans-2-enoyl-CoA; Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18); Family membership.
  
  
 
0.910
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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