Alpha-galactosidase, family GH110; Alpha-galactosidase catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides. Belongs to the family 110 of the glycoside hydrolases. Likely adopts a right handed parallel beta-helix fold. Signal peptide cleaved between the residues 19 and 20. Localized in the periplasmic space; High confidence in function and specificity.

Sulfatase, family S1-16; The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates; Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases), subfamily 16; Signal peptide cleaved between the residues 19 and 20; Localized in the periplasmic space; Family membership.

Sulfatase, family S1-20; Modular protein consisting of a N-terminal domain belonging to the family 1 of sulfatases and a C-terminal PA14 domain putatively involved in the protein or carbohydrate binding; The family 1 of sulfatases is composed of enzymes that require the posttranslational oxidation of a conserved cysteine (or serine) to a catalytic formylglycine to hydrolyze various sulfate ester substrates; Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases), subfamily 20; Contains a lipoprotein signal peptide cleaved between the residues 22 and 23; Localized [...]

The N-sulfoglucosamine sulfohydrolase, called also Sulfoglucosamine sulfamidase is involved in the glycosaminoglycan degradation. It hydrolyzes the N-sulfate groups from the D-glucosamine-N-sulfate-6-O-sulfate residues in heparan sulfate and heparin; Belongs to the family 1 of sulfatases (S1: formylglycine-dependent sulfatases), subfamily 8; Signal peptide putatively cleaved between the residues 25 and 26; Possibly localized in the periplasmic space; High confidence in function and specificity.

SusD/RagB family lipoprotein; Protein probably involved in nutrient binding and belonging to the SusD/RagB family; Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer; Contains a lipoprotein signal peptide cleaved between the residues 22 and 23; Probably localized in the outer membrane; Family membership.

TonB-dependent Receptor; Protein localized in the outer membrane involved in uptake of macromolecules (here, the sulphated sugars) that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations; Contains a carboxypeptidase regulatory domain (35-109) and the Plug module (125-232) acting as a channel gate; The signal peptide is cleaved between the residues 32 and 33; Family membership.

Iota-carrageenase, family GH82; The Iota-carrageenases hydrolyse the 1,4-beta-D-galactosidic linkages in the iota-carrgeenan giving the tetramer as the predominant product; Belongs to the family 82 of glycoside hydrolases (GH82); Signal peptide of lipoprotein cleaved between the residues 19 and 20; Localized in the outer membrane; High confidence in function and specificity.

C-alpha-formylglycine-generating protein; Converts newly synthesized inactive sulfatases to their active form by modifying an active site cysteine or serine residue to 3-oxoalanine; Putatively localized in the outer membrane; Specificity unclear.

The sensor proteins consist of a sensing beta-propeller fold periplasmic domain, variable in sequence, reflective of the many different environmental signals, and of a cytoplasmic part composed of a histidine kinase domain, a response regulator receiver domain and a response regulator effector domain (here a C-terminal AraC- type HTH domain); Contains one transmembrane segment; Localized in the cytoplasmic membrane; Family membership.