STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
coxNCytochrome c oxidase is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen catalyzing the reduction of oxygen to water; Subunit I (CO I) is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred, via the copper A center of subunit II and a low-spin heme (heme a) of subunit 1, to the CuB-heme a3 (or heme o) bimetallic center of subunit 1; contains 12 transmembrane segmemts; Localized in the cytoplasmic membrane; High confidence in function and specificity. (609 aa)    
Predicted Functional Partners:
coxM
Cytochrome c oxidase, subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 0.999
coxC/ctaE
Associates with subunits I, II and IV to form cytochrome c oxidase the terminal enzyme of the respiratory chain; The functional role of subunit III is not yet understood; Contains five transmembrane segmemts; Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
 0.999
cyoC
Cytochrome O ubiquinol oxidase, subunit III; Cytochrome O terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration; Heterooctamer of two A chains, two B chains, two C chains and two D chains; Contains five transmembrane segmemts; Localized in the cytoplasmic membrane; Family membership.
 
 0.999
cyoE/ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
 
 0.996
CAZ96942.1
Rieske [2Fe-2S] iron-sulfur protein; Protein that contains an unknown function N-terminal domain and a C-terminal Rieske [2Fe-2S] domain; The rieske domain has a [2Fe-2S] centre. Two conserved cysteines that one Fe ion while the other Fe ion is coordinated by two conserved histidines; Prokaryotic lipoprotein signal peptide cleaved between the residues 25 and 26; Localized in the outer membrane; Function unclear.
  
 
 0.974
ccoP
Cytochrome cbb3 oxidase, CcoP subunit; Belongs to the ccoNOPQ operon. Features three transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
 0.938
ccoQ
CcoQ is a subunit of the cytochrome cbb3 oxidase. Converts the ferrocytochrome c to ferricytochrome c. Belongs to the ccoNOPQ operon. Contains one transmembrane helix; Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
 0.938
ccoNO
Fusion of the subunits CcoN and CcoO of the Cytochrome cbb3 oxidase. Converts the ferrocytochrome to ferricytochrome. Belongs to the ccoNOQP operon. Contains 13 transmembrane helices; Localized in the cytoplasmic membrane; High confidence in function and specificity.
    
0.936
CAZ96537.1
Conserved hypothetical membrane protein; Contains three transmembrane segments; Localized in the cytoplasmic membrane; Conserved hypothetical protein.
 
  
 0.929
CAZ95340.1
Conserved protein belonging to the DUF477 family; Contains three transmembrane helices in the C-terminal region; Signal peptide cleaved between the residues 19 and 20; Localized in the cytoplasmic membrane; Family membership.
 
 
   0.875
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.