STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
Score
rnrB2The small subunit of the ribonucleoside-diphosphate reductase is a part of a complex which is an heterotetramer of two large and two small subunits. The complex catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Contains a N- terminal evolutionarily mobile, ATP-binding regulatory domain (ATP cone domain) which binds either ATP (activating) or dATP (inhibitory). Substrate binding to the ATP cone domain is thought to alter the relative positions of the two subunits of ribonucleoside- diphosphate reductase; Binds two iron ions by subunit; Localized [...] (424 aa)    
Predicted Functional Partners:
rnrA2
The large subunit of the ribonucleoside-diphosphate reductase, is a part of a complex which is an heterotetramer of two large and two small subunits. The complex catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.999
rnrA1
Ribonucleoside-diphosphate reductase, large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 0.994
hptA/adkA
Bifunctional protein Hypoxanthine-guanine phosphoribosyltransferase / Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
    
 0.949
rnrB1
Ribonucleoside-diphosphate reductase is an heterotetramer of two large and two small subunits. It catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. This gene codes the small subunit. It binds two iron ions by subunit. This complex is localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.935
ndkA
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.929
cmk
Cytidylate kinase is involved in pyrimidine nucleotide metabolism. It catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP. Localized in the cytoplasm; High confidence in function and specificity.
    
 0.917
gmkA
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.915
pykA
Pyruvate kinase (PK) catalyzes the final step in glycolysis (Embden-Meyerhof pathway), the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP. PK forms a homotetramer and requires both magnesium and potassium ions for its activity. PK helps control the rate of glycolysis, along with phosphofructokinase and hexokinase. PK possesses allosteric sites for numerous effectors; Localized in the cytoplasm; High confidence in function and specificity.
     
 0.911
queE
Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
 
 0.910
relA
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.907
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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