STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
purKN5-carboxyaminoimidazole ribonucleotide synthetase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (390 aa)    
Predicted Functional Partners:
purE
N5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
 0.999
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.999
purM
Phosphoribosylformylglycinamidine cyclo-ligase is involved in purine biosynthesis. It catalyzes the reaction: ATP + 2-(formamido)-N1-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.988
purD
Phosphoribosylamine glycine ligase (also known as phosphoribosylglycinamide synthetase) catalyses the second step in the de novo biosynthesis of purine: the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. Localized in the cytoplasm; High confidence in function and specificity; Belongs to the GARS family.
 
  
 0.955
purH
Bifunctional enzyme that catalyses the last two steps in de novo purine biosynthesis. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) formyltransferase that catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield 5-formylaminoimidazole-4-carboxamide ribonucleotide (FAICAR) and tetrahydrofolate. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase, cyclizing FAICAR to IMP; Belongs to the purH family; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.941
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
  
 0.925
purF
Amidophosphoribosyltransferase catalyzes the first step in purine biosynthesis: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PurF belongs to the Class-II glutamine amidotransferase family. It forms a homotetramer and binds one magnesium ion per subunit. Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.903
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase catalyzes the seventh step in the de novo purine biosynthetic pathway: the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR. It forms a homotrimer. Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.892
purB
Adenylosuccinate lyase catalyzes step 8 in the pathway for de novo synthesis of IMP and also the final reaction in the two-step sequence from IMP to AMP. It cleaves succinylaminoimidazole carboxamide ribotide into aminoimidazole carboxamide ribotide and fumarate, as well as adenylosuccinate into adenylate and fumarate. Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.878
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
     
  0.800
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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