STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
idnO3Gluconate-5-dehydrogenase; Also called 5-keto-D-gluconate 5-reductase; Catalyzes the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate using NADP as a coenzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Localized in the cytoplasm; High confidence in function and specificity. (264 aa)    
Predicted Functional Partners:
mdmC
MdmC is a 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 
 0.796
uglA1
Unsaturated glucuronyl hydrolase, family GH88; Unsaturated glucuronyl hydrolase is involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. UglA catalyzes the hydrolysis of oligosaccharides with unsaturated uronic acids at the nonreducing terminal, to a sugar or an amino sugar, and an unsaturated uronic acid, which is nonenzymatically converted immediately to alpha-keto acid; Belongs to the family 88 of the glycoside hydrolases (GH88); Signal peptide cleaved between residues 22 and 23. Localized in the periplasmic space; Specificity unclear.
 
     0.546
uglA2
Unsaturated glucuronyl hydrolase, family GH88; Unsaturated glucuronyl hydrolase is involved in the catabolism of unsaturated oligosaccharides produced by polysaccharide lyases. UglA catalyzes the hydrolysis of oligosaccharides with unsaturated uronic acids at the nonreducing terminal, to a sugar or an amino sugar, and an unsaturated uronic acid, which is nonenzymatically converted immediately to alpha-keto acid; Belongs to the family 88 of the glycoside hydrolases (GH88); Signal peptide cleaved between residues 22 and 23; Localized in the periplasmic space; Specificity unclear.
 
     0.531
CAZ94326.1
Sodium/solute symporter; Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force, SMF) is used to drive solute accumulation against a concentration gradient; Contains 13 transmembrane helices; Localized in the cytoplasmic membrane; Family membership; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
       0.523
gntK2
Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate; GntK adopts an alpha/beta fold, consisting of a central sheet of five parallel beta-strands flanked by alpha-helices; Belongs to the shikimate kinase family; Localized in the cytoplasm; High confidence in function and specificity.
   
 0.508
CAZ94457.1
Type I polyketide synthases are modular enzymes involved in the synthesis of various polyketides. This enzyme encompasses five modules: beta-ketoacyl synthase (KS), acyltransferase (AC), dehydratase (DH), enoyl reductase (ER) and acyl carrier protein (ACP). This modular enzyme is homologous to mycocerosic acid synthase (EC 2.3.1.111). Binds 1 phosphopantetheine group covalently. Localized in the cytoplasmic membrane; Specificity unclear.
  
 
 0.507
fabD
Malonyl CoA-acyl carrier protein transacylase is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein; High confidence in function and specificity.
 
 
 0.469
CAZ97947.1
Conserved hypothetical protein; Localized in the cytoplasm.
 
     0.446
pfkB
6-Phosphofructokinase, isozyme 2; 6-Phosphofructokinase catalyzes the thirth step of glycolysis (Embden-Meyerhof pathway). It phosphoryles the D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. It is an allosteric homodimer enzyme. Because the reaction catalyzed by Phosphofructokinase is energetically very favorable, it is essentially irreversible; Belongs to the carbohydrate kinase PfkB family; Localized in the cytoplasm; High confidence in function and specificity.
   
  
 0.433
CAZ94267.1
Conserved hypothetical lipoprotein; Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 19 and 20; Localized in the outer membrane; Conserved hypothetical protein.
 
     0.423
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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