STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ96754.1Nuclease; Contains a N-terminal exonuclease domain found in ribonuclease T and the epsilon subunit of DNA polymerase III and, in the middle part, a GIY-YIG catalytic domain Localized in the cytoplasm; Function unclear. (461 aa)    
Predicted Functional Partners:
dnaE1
The alpha subunit of DNA polymerase III is responsible of the polymerase activity; Contains a N-terminal exonuclease domain, a PHP domain (phosphoesterase) and a C-terminal OB module (oligonucleotide /oligosaccharide-binding fold) involved in the DNA binding; The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity; Localized in the cytoplasm; High confidence in function and specificity.
    
 0.960
CAZ98630.1
Conserved hypothetical protein. Localized in the cytoplasm.
 
  
 0.945
dnaX
DNA polymerase III, gamma/tau chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.944
dnaQ
The epsilon subunit of DNA polymerase III is responsible of the proofreading 3'-5' exonuclease activity; The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It exhibits a DNA polymerase activity (alpha chain) and a 3' to 5' exonuclease proofreading activity; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.943
CAZ98889.1
Nuclease; Contains a N-terminal exonuclease domain found in ribonuclease T and the epsilon subunit of DNA polymerase III and, in the middle part, a GIY-YIG catalytic domain Localized in the cytoplasm; Function unclear.
 
  
0.940
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
   
 0.934
CAZ94670.1
This Exonuclease probably exhibits a 3' to 5' deoxyribonuclease activity or a ribonuclease activity; Contains an exonuclease domain; Localized in the cytoplasm; Family membership.
    
0.921
holB
The delta prime subunit of DNA polymerase III is part of the 'clamp' loading complex that assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork; The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity; Localized in the cytoplasm; High confidence in function and specificity.
   
 
 0.918
uvrB
Excinuclease ABC, subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 
 0.890
uvrD
DNA helicase unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Contains a uvrD-like helicase ATP-binding domain and a uvrD-like helicase C-terminal domain; Belongs to the helicase family, UvrD subfamily Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.715
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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