STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
CAZ96976.1Sigma-54 dependent two-component system-Response regulator; These response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes, activating the expression of genes from factor sigma-54 specific promoters. These proteins consist of two domains, an N- terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor, and a C- terminal domain that interacts with the sigma 54 factor; Family membership. (387 aa)    
Predicted Functional Partners:
CAZ95929.1
The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain; Contains an HAMP domain and one transmembrane segments; Localized in the cytoplasmic membrane; Family membership.
 0.970
CAZ98039.1
The sensor histidine kinase belongs to two-component signal transduction systems. It autophosphorylates an histidine in its phosphoacceptor domain and phosphorylates an aspartic acid present in the response regulator receiver domain; Contains a CheB-type methylesterase catalytic domain and a CheR-type methyltransferase domain, both involved in the bacterial chemotaxis system; Contains a PAS/PAC domain; Seems localized in the cytoplasm; Family membership.
  
 
 0.843
rpoN
RNA polymerase sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. sigma-54 factors consist of three distinct regions: A conserved N-terminal glutamine-rich region (50 aa) that contains a potential leucine zipper motif. A region which is not conserved. A conserved C-terminal region (350 aa) that contains a second potential leucine zipper, a potential DNA-binding 'helix-turn-helix' motif and a perfectly conserved octapeptide whose function is not known; Localized in the cytoplasm; High confidenc [...]
 
  
 0.799
CAZ96975.1
Conserved hypothetical protein; Localized in the cytoplasm.
       0.756
CAZ97725.1
The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain; Possibly localized in the cytoplasm; Family membership.
 
 
 0.567
CAZ94899.1
Conserved hypothetical protein; Signal peptide cleaved between the residues 18 and 19; Possibly localized in the outer membrane.
  
  
 0.555
CAZ96973.1
ABC-2 type exporter, permease component; Putatif ABC-2 type (ATP-binding cassette) transporter, membrane domain possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics, heavy metals or solvents across biological membranes; Contains seven transmembrane segments; The proteins form homo- or hetero-oligomeric channels, allowing ATP-mediated transport; Localized in the cytoplasmic membrane; Family membership.
       0.524
CAZ96972.1
ABC transporter, ATPase component; This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase); Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane); Localized in the cytoplasm near of the cytoplasmic membrane by association with the permease component; Family membership.
       0.523
CAZ96974.1
Mechanosensitive channels (MS) provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation; Contains four transmembrane helices; Belongs to the small-conductance MS channels; Localized in the cytoplasmic membrane; Specificity unclear.
       0.519
rho
Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
 
   
 0.480
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.