STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
crtIPhytoene dehydrogenase or phytoene desaturase is involved in carotenoid biosynthesis that converts phytoene into zeta-carotene via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene; Uses the FAD as cofactor; Belongs to the carotenoid/retinoid oxidoreductase family; Possible signal peptide of lipoprotein cleaved between thez residues 18 and 19; Possibly localized in the outer membrane; High confidence in function and specificity. (485 aa)    
Predicted Functional Partners:
crtB
The phytoene synthetase (PSY) catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. The reaction carried out by PSY is catalyzed in two separate steps: the first is a head-to-head condensation of the two molecules of GGPP to form prephytoene diphosphate, this intermediate is then rearranged to form phytoene; Belongs to the phytoene/squalene synthetase family; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.999
crtZ
Carotene hydroxylase, involved in the carotenoid biosynthesis, catalyzes the hydroxylation of both beta rings of beta-carotene to form zeaxanthine; Contains three transmembrane segments; Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
   
 0.975
crtY
Lycopene cyclase; Catalyzes the double cyclization reaction which converts lycopene to beta-carotene; Involved in the carotenoid biosynthesis; contains a N-terminal transmembrane segment; Putatively localized in the cytoplasmic membrane; Family membership.
 
 
 0.970
CAZ97122.1
The MerR-type transcriptional regulators contain a helix-turn-helix (HTH) DNA-binding motif involved in the binding of the protein to the operator sequences in the DNA. The HTH domain, located in the N-terminal part of these proteins, is followed by a coiled-coil region. The C-terminal part contains effector binding regions that are specific to the effector recognized; Localized in the cytoplasm; Family membership.
 
  
 0.890
phrA
Deoxyribodipyrimidine photo-lyase is involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. It binds a reduced FAD moiety as prosthetic group, and, in addition, either a reduced pterin or 8-hydroxy-5-diazaflavin as a second chromophore; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.658
CAZ96710.1
Protein That uses nucleotide-sugar substrates for a variety of chemical reactions using NAD as cofactor; Contains a C-terminal transmembrane segment; Localized in the cytoplasmic membrane; Specificity unclear.
 
   
 0.457
CAZ97123.1
Hypothetical membrane protein; Contains one transmembrane helix; Localized in the cytoplasmic membrane; Hypothetical protein.
       0.406
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.