STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
CAZ97125.1The HNOB (Heme NO Binding) module, is a predominantly alpha-helical module and binds heme via a covalent linkage to histidine. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals; Probably, acts as effector domain belonging to a two-component system; Family membership. (186 aa)    
Predicted Functional Partners:
CAZ97126.1
The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain; Contains three N-terminal PAS/PAC domains involved in many signalling proteins where they are used as a signal sensor domain; Seems localized in the cytoplasm; Family membership.
 
   
 0.960
CAZ97129.1
The histidine-containing phosphotransfer (HPt) domain is a protein module that mediates phosphotransfer reactions in the two-component signaling systems; HPt modules (~120 residues) contain a histidine residue capable of participating in phosphoryl transfer reactions. They serve as a phosphoreceiver and phosphodonor in order to shuttle phosphoryl groups between two or more response regulator domains; Family membership.
 
     0.950
CAZ97127.1
Conserved hypothetical protein; Probably localized in the cytoplasm.
 
   
 0.931
CAZ97128.1
The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain; Possibly localized in the cytoplasm; Family membership.
 
     0.915
CAZ97463.1
Radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S center. The exact function of this protein is unclear. Localized in the cytoplasm; Family membership.
 
  
 0.885
CAZ97130.1
The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. The protein consists of two domains, an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor, and a variable C-terminal effector domain with DNA-binding activity, a LytTR-type HTH domain, which acts as transcriptional regulator; Family membership.
 
     0.834
CAZ97124.1
Two-component system-Response regulator, receiver domain; The response regulator proteins are involved in the two-component signal transduction systems to detect and respond to environmental changes. Usually, the protein consists of two domains, an N-terminal response regulator receiver domain that is substrate for a histidine protein kinase sensor, and a variable C-terminal effector domain with DNA-binding activity which acts as transcriptional regulator; Family membership.
 
     0.785
CAZ96439.1
Conserved hypothetical protein; Localized in the cytoplasm.
  
     0.756
ppk2
Polyphosphate kinase 2; Ppk2 was first identified in Pseudomonas aeruginosa by Zhang and cowokers (PNAS, 2006). Ppk2 belongs to a polyphosphate kinase family unrelated to that of Ppk1. Pkk2 also distinguished from PPK1 by the following: synthesis of poly P from GTP or ATP, a preference for Mn2+ over Mg2+, and a stimulation by poly P. The reverse reaction, a poly P-driven nucleoside diphosphate kinase synthesis of GTP from GDP, is 75-fold greater than the forward reaction, poly P synthesis from GTP. Localized in the cytoplasm; High confidence in function and specificity.
   
    0.688
CAZ97131.1
TPR repeats protein; Protein containing three tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes; Signal peptide cleaved between the residues 19 and 20; Localized in the periplasmic space; Function unclear.
  
     0.683
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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