STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ97149.1Glycerophosphodiester phosphodiesterase protein family; Protein that contains a N-terminal Phosphatidylinositol-specific phospholipase X-box domain; Belongs to the glycerophosphoryl diester phosphodiesterase family; Signal peptide of lipoprotein cleaved between the residues 17 and 18; Localized in the outer membrane; Family membership. (316 aa)    
Predicted Functional Partners:
CAZ97150.1
SusD/RagB family lipoprotein; Protein probably involved in nutrient binding and belonging to the SusD/RagB family; Gene very often associated with a gene encoding for a TonB-dependent receptor or transducer; Contains a lipoprotein signal peptide cleaved between the residues 18 and 19; Probably localized in the outer membrane; Family membership.
 
     0.860
CAZ97151.1
TonB-dependent Transducer; Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins; The presence of an additional N-terminal extension (Secretin/TonB (STN) domain) that probably interacts with an anti-sigma factor, would be responsible of the signal transduction; Contains a N-terminal carboxypeptidase regulatory domain (117-190), a Plug module (206-316) acting as the channel gate; The signal peptide is cleaved between the residue 22 and 23; Family membership.
 
     0.837
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
  
 0.608
CAZ97152.1
Anti-sigma factor; This protein would be an intermediate between a TonB-dependant transducer and a ECF sigma factor in the transmission of a signal from outside towards the cytoplasm; Contains a C-terminal domain that displays similarities with the anti-sigma factors of the FecR/PupR family; The N-terminal domain, without similarities, would interact with the N-terminal extension found in the TonB-dependant transducers; Protein localized in the cytoplasmic membrane; Family membership.
 
     0.498
cda2
Cda is a calcium-dependent ATPase. Vanadate strongly inhibits its activity; Belongs to the alkaline phosphatase clan, type I phosphodiesterase family; Signal peptide cleaved between the residues 19 and 20; Localized in the periplasmic space; High confidence in function and specificity.
  
  
 0.438
aqpZ
Aquaporin Z; Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
 
 0.412
glpF
Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane. Belongs to the Major Intrinsinc Protein family which also includes aquaporin. Features six transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
 
 0.412
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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