STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
siaE1Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid; Signal peptide cleaved between the residues 21 and 22; Localized in the periplasmic space; High confidence in function and specificity. (462 aa)    
Predicted Functional Partners:
CAZ97662.1
Modular protein with a N-terminal acetylesterase (lipase-GDSL family), which includes families 3 and 12 of the carbohydrate esterases (CE3 and CE12), a central alpha/beta hydrolase fold domain and a C-terminal GDSL_hydrolase fold domain; Signal peptide cleaved between the residues 21 and 22; Localized in the periplasmic space; Specificity unclear.
 
     0.875
CAZ97763.1
Carbohydrate esterase, family CE4; Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides; Belongs to the family 4 of carbohydrate esterases (CE4). These proteins fold into a 7-stranded beta/alpha barrel; Signal peptide cleaved between residues 20 and 21; Localized in the periplasmic space; Specificity unclear.
   
 0.790
CAZ97315.1
Conserved hypothetical membrane protein; Contains a putative lipoprotein signal peptide cleaved between the residues 22 and 23; Possibly localized in the outer membrane; Conserved hypothetical protein.
   
 
 0.680
paeX
Pectin acetylesterase, family CE10; Pectin acetylesterase hydrolyzes acetyl groups in pectins, releasing acetates. This enzyme belongs to the family 10 of the carbohydrate esterases. Features a signal peptide cleaved between residues 18 and 19. Localized in the periplasm; High confidence in function and specificity.
 
   
 0.584
nanH
Sialidase, family GH33; Sialidase catalyzes the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. It belongs to the family 33 of the glycoside hydrolases. Features a signal peptide cleaved between residues 26 and 27. Localized in the periplasm; High confidence in function and specificity.
     0.583
CAZ97313.1
NAD(P)-dependent dehydrogenase belonging to the Rossmann fold family; Contains a twin-arginine translocation signal peptide cleaved between the residues 30 and 31; Localized in the periplasmic space; Specificity unclear.
       0.537
CAZ96369.1
Acetylesterase that belongs to the lipase-GDSL Pfam family, which includes families 3 and 12 of the carbohydrate esterases (CE3, CE12); The conserved catalytic residues are Ser38, Asp194 and His197. Lipoprotein signal peptide cleaved between the residues 21 and 22; Localized in the outer membrane; Specificity unclear.
     0.456
CAZ95101.1
N-acetyl-D-glucosamine 2-epimerase catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. It functions as a homodimer, where monomer has an alpha(6)/alpha(6)-barrel structure commonly found in glucoamylases and cellulases This enzyme is involved in sialic acid metabolism. Localized in the cytoplasm; High confidence in function and specificity.
 
     0.412
CAZ94327.1
Hypothetical periplasmic protein; Signal peptide cleaved between the residues 22 and 23; Localized in the periplasmic space; Hypothetical protein.
 
 
 
 0.412
CAZ97060.1
Carbohydrate esterase, family CE10; Carbohydrate esterases catalyze the de-O or de-N-acetylation of substituted saccharides; Belongs to the family 10 of the carbohydrate esterases (CE10); Signal peptide cleaved between residues 19 and 20; Localized in the periplasmic space; Specificity unclear.
 
   
 0.405
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.