STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ97624.1Conserved hypothetical protein; Localized in the cytoplasm. (332 aa)    
Predicted Functional Partners:
CAZ97575.1
TonB-dependent Receptor; Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations; Contains a carboxypeptidase regulatory domain (21-95) and the Plug module (109-215) acting as a channel gate; The signal peptide is cleaved between the residues 20 and 21; Family membership.
  
     0.703
CAZ97570.1
The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous, solvent-accessible conduit that spans both the outer membrane and periplasmic space; May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria (type I secretion system); Signal peptide cleaved between the residues 19 and 20; Localized in the outer membrane; Family membership.
  
     0.693
CAZ94368.1
This protein belongs to the Heavy metal transport protein family. The Heavy-Metal-Associated (HMA) domain contains two conserved cysteines that are probably involved in metal binding. Its structure comprises our- stranded antiparallel beta-sheet and two alpha helices packed in an alpha-beta sandwich fold. Somes of these HMA proteins are involved in bacterial resistance to toxic metals, such as lead and cadmium. Localized in the cytoplasm; Specificity unclear.
 
     0.664
CAZ97571.1
These membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics, solvents or heavy metals; Proteins of the MFP family function as 'adaptors', connecting a ABC transporters, localized in the cytoplasmic membrane, with a porin or channel localized in outer membrane; The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region; Family membership.
  
     0.646
CAZ97572.1
Multidrug efflux transporter; Integral membrane protein involved in drug resistance that belongs to the acrB/acrD/acrF family; Contains 12 transmembrane segments and two large periplasmic domains (each exceeding 300 residues) between helices 1 and 2, and helices 7 and 8. The three transmembrane domains form a large, 30-wide central cavity that spans the cytoplasmic membrane and extends to the cytoplasm; Localized in the cytoplasmic membrane; Family membership; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
    0.609
trxA-3
Thioredoxin is a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase; Localized in the cytoplasm; High confidence in function and specificity.
       0.525
nosZ
Nitrous-oxide reductase is a copper-containing enzyme that catalyses the two-electron reduction of the greenhouse gas N2O to N2. It is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide. Homodimer that Binds 6 copper ions per subunit. Signal peptide of lipoprotein cleaved between the residues 20 and 21. Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
    0.521
CAZ97573.1
Conserved hypothetical protein; Localized in the cytoplasm.
  
     0.507
CAZ97576.1
Conserved hypothetical protein; Localized in the cytoplasm.
  
     0.498
CAZ97619.1
Mechanosensitive channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation; Contains three transmembrane helices; Belongs to the small-conductance MS channels; Localized in the cytoplasmic membrane; Specificity unclear.
 
     0.490
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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