STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
gdhA2Glutamate dehydrogenase catalyzes the NAD- and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate. It is involved with either ammonia assimilation or glutamate catabolism. Forms a homohexamer and binds one NAD(P) cofactor by subunit. Localized in the cytoplasm; High confidence in function and specificity; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (430 aa)    
Predicted Functional Partners:
gltA-2
Glutamate synthase [NADPH] large chain; Glutamate synthase is a key enzyme in the early stages of the assimilation of ammonia. It is a complex iron-sulfur flavoprotein catalyzing the reductive transfer of the amido nitrogen from L-glutamine to 2-oxoglutarate to form two molecules of L-glutamate via intramolecular channelling of ammonia from the amidotransferase domain to the FMN-binding domain. Glutamate synthase forms an aggregate of 4 catalytic active heterodimers, consisting of a large and a small subunit (GltB). GltA binds as cofactors a 3Fe-4S cluster, a FAD and a FMN. Localized i [...]
  
 0.999
gltB
Glutamate synthase [NADPH] small chain; Glutamate synthase is a key enzyme in the early stages of the assimilation of ammonia. It is a complex iron-sulfur flavoprotein catalyzing the reductive transfer of the amido nitrogen from L-glutamine to 2-oxoglutarate to form two molecules of L-glutamate via intramolecular channelling of ammonia from the amidotransferase domain to the FMN-binding domain. Glutamate synthase forms an aggregate of 4 catalytic active heterodimers, consisting of a large (GltA) and a small subunit. GltB binds NADP(H) as a cofactor. Localized in the cytoplasm; High con [...]
  
 0.939
gdhA1
Glutamate dehydrogenase catalyzes the NAD- and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate. It is involved with either ammonia assimilation or glutamate catabolism. Forms a homohexamer and binds one NAD(P) cofactor by subunit. Localized in the cytoplasm; High confidence in function and specificity; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
  
 
0.921
nitA
Nitrilases, involved in the reduction of organic nitrogen compounds and ammonia production, are enzymes that convert nitriles into their corresponding acids and ammonia by cleavage of the carbon-nitrogen bonds. They acts on a wide range of aromatic nitriles including (indol- 3-yl)-acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides; Belongs to the CN hydrolase family; Localized in the cytoplasm; Specificity unclear.
   
 
 0.918
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
  
 
 0.917
glnII
Glutamine synthetase (GS), also known as Glutamate-ammonia ligase, plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. Belongs to the GS class II which is usually found in eukaryotes and in bacteria belonging to the Rhizobiaceae, Frankiaceae, and Streptomycetaceae families. GSII are octamer of identical subunits. Localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.915
pruA
1-pyrroline-5-carboxylate dehydrogenase is involved in L-proline degradation. It catalyzes the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH. Belongs to the aldehyde dehydrogenase family and uses NAD as cofactor. Localized in the cytoplasm; High confidence in function and specificity.
  
 0.913
glnA
Glutamine synthetase (GS), also known as Glutamate-ammonia ligase, plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. Belongs to the GS class III which includes GS from Bacteroides fragilis and Butyrivibrio fibrisolvens. GSIII enzymes are much larger (about 700 amino acids) than the GSI (450 to 470 amino acids) or GSII (350 to 420 amino acids) enzymes. It forms a hexamer. Localized in the cytoplasm; High confidence in function and specificity.
     
 0.911
nirB
Nitrite reductase, required for nitrite assimilation (reducing nitrite to ammonia), catalyzes the second step of nitrate assimilation (denitrification); Binds 1 siroheme and 1 2Fe-2S cluster, uses FAD as cofactor; It is an homodimer which associates with nirD; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family; Localized in the cytoplasm; High confidence in function and specificity.
   
 
 0.909
glsA
Glutaminase catalyzes the reaction: L-glutamine + H2O = L-glutamate + NH3. Localized in the cytoplasm; High confidence in function and specificity.
     
 0.909
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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