STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
thiDPhosphomethylpyrimidine kinase also known as HMP(Hydroxymethylpyrimidine)-phosphate kinase catalyzes the phosphorylation of HMP-P to HMP-PP during the biosynthesis of thiamine; It is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes; Localized in the cytoplasm; High confidence in function and specificity. (265 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
 
 0.993
CAZ97793.1
Conserved protein distantly related to Thiamine-phosphate synthase (ThiE); Localized in the cytoplasm; Function unclear.
 
 
 0.985
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.859
moeB
Molybdopterin synthase activating protein; Enzyme involved in the biosynthesis of molybdopterin cofactor, necessary for molybdoenzymes. Plays a role in the activation of the small subunit of the molybdopterin converting factor (moaD); Contains a N- terminal transmembrane segment and a C-terminal rhodanese domain; Belongs to the hesA/moeB/thiF family; Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
 0.783
thiS
ThiS is involved in sulphur transfer during the thiamine biosynthesis pathway. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS; Contains two conserved glycines at the C-terminus; Localized in the cytoplasm; High confidence in function and specificity.
  
    0.767
CAZ95123.1
DEAD/DEAH RNA helicase; Protein that could be involved in ATP-dependent RNA unwinding in a variety of cellular processes, including ribosome assembly, protein synthesis, and RNA degradation; Contains a DEAD box; Belongs to the helicases superfamily II, DEAD/DEAH box RNA helicase family, DEAD box subfamily; Localized in the cytoplasm; Family membership.
 
   0.715
CAZ96836.1
Hypothetical membrane protein; Contains three transmembrane helices; Localized in the cytoplasmic membrane; Hypothetical protein.
  
  
 0.694
truA1
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.481
truA2
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.481
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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