STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
CAZ97827.1Serine endopeptidase belonging to the family S54. This family includes the protein Rhomboid which is a peptidase important for embryo development in Drosophila melanogaster. The active site is a catalytic diad Ser, His. Features seven transmembrane helices. Localized in the cytoplasmic membrane; Specificity unclear. (289 aa)    
Predicted Functional Partners:
CAZ97828.1
Serine endopeptidase belonging to the family S54. This family includes the protein Rhomboid which is a peptidase important for embryo development in Drosophila melanogaster. The active site is a catalytic diad Ser, His. Features six transmembrane helices. Localized in the cytoplasmic membrane; Specificity unclear.
 
    
0.859
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
  
    0.824
CAZ97826.1
The Endonuclease/exonuclease/phosphatase domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling; Contains two N-terminal transmembrane segments; Belongs to the Endonuclease/Exonuclease/ phosphatase family; Possible signal peptide of lipoprotein cleaved between the residues 25 and 26; Localized in the cytoplasmic membrane; Family membership.
       0.820
CAZ97830.1
Conserved hypothetical membrane protein; Contains a C-terminal transmembrane helix; Localized in the cytoplasmic membrane; Conserved hypothetical protein.
       0.820
CAZ97832.1
TPR repeats protein; Conserved protein containing three C-terminal tetratrico peptide repeats (TPRs). TPR repeats mediate proteinprotein interactions and the assembly of multiprotein complexes; Contains a transmembrane helix in the N-terminal region; Localized in the cytoplasmic membrane; Function unclear.
 
     0.561
ribH
Riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
       0.497
tatA
Sec-independent protein translocase TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
  
 
 0.457
MthfS
Methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclodehydrase) catalyzes the ATP-and Mg2+-dependent transformation of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate. Localized in the cytoplasm; High confidence in function and specificity.
  
    0.440
CAZ94673.1
Sodium/solute symporter; Sodium/substrate symport is a widespread mechanism of solute transport across cytoplasmic membranes of cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force, SMF) is used to drive solute accumulation against a concentration gradient; Contains 13 transmembrane helices; Localized in the cytoplasmic membrane; Specificity unclear; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
     0.418
CAZ97835.1
Conserved hypothetical protein; Localized in the cytoplasm.
 
     0.415
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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