STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wbpPUDP-N-acetylglucosamine 4-epimerase converts the UDP-N-acetyl-D-glucosamine to UDP-N-acetyl-D-galactosamine. WbpP is involved in the nucleotide sugar metabolism and in the lipopolysaccharide biosynthesis; Belongs to the NAD dependent epimerase/dehydratase family, Rossmann fold Superfamily; Localized in the cytoplasm; High confidence in function and specificity. (332 aa)    
Predicted Functional Partners:
vipA
VipA is involved in the biosynthesis of an exopolysaccharide. In Salmonella typhi, this EPS is the Vi antigen. VipA belongs to the UDP-glucose/GDP-mannose dehydrogenase family, a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate. Localized in the cytoplasm; High confidence in function and specificity.
 
 0.993
CAZ95197.1
NAD(P)-dependent oxidoreductase that adopts a Rossmann fold; belongs to the GFO/IDH/MOCA family; Localized in the cytoplasm; Specificity unclear.
  
 
  0.905
wbpB
WbpB is a NAD(P)-dependent oxidoreductase involved in lipopolysaccharide biosynthesis; Belongs to the GFO/IDH/MOCA family; Adopts a Rossmann fold; Localized in the cytoplasm; Specificity unclear.
  
 
  0.905
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
    
 0.904
lpxA
Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
 
 0.816
algD
GDP-mannose 6-dehydrogenase catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid. In Pseudomonas aeruginosa, this activated sugar is the precursor for alginate polymerization. AlgD belongs to the UDP-glucose/GDP- mannose dehydrogenase family, a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate. Localized in the cytoplasm; High confidence in function and specificity.
 
 0.639
CAZ96058.1
Glycosyltransferase, family GT4; Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm; Specificity unclear.
 
    0.627
CAZ97904.1
Glycosyltransferase, family GT4; Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. Localized in the cytoplasm; Specificity unclear.
 
    0.611
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 0.592
capM
Capsular polysaccharide biosynthesis glycosyltransferase, family GT4; Glycosyltransferase catalyses the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Belongs to the family 4 of the glycosyltransferases. This enzyme is likely involved in the biosynthesis of exopolysaccharides. Localized in the cytoplasm; Specificity unclear.
 
    0.545
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.