STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ttuCTartrate dehydrogenase/decarboxylase has multiple catalytic activities. Apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate, also converts meso-tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate. It uses NAD+ as a cofactor. Belongs to the Isocitrate dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity. (354 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase is a complex of a large catalytic chain and a smaller regulatory chain associated in an alpha2/beta2 heterotetramer. It catalyzes the first step of the isoleucine and valine biosynthesic pathways. The regulatory subunit, IlvH, features an ACT domain. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.975
ilvB
Acetolactate synthase is a complex of a large catalytic chain and a small regulatory chain associated in an alpha2/beta2 heterotetramer. It catalyzes the first step of the isoleucine and valine biosynthesic pathways. The catalytic subunit, IlvB, is a thiamine pyrophosphate-dependent enzyme. It also binds one magnesium ion and one FAD per subunit, although the role of this cofactor is not clear considering that the reaction does not involve redox chemistry; Localized in the cytoplasm; High confidence in function and specificity.
 0.973
leuC
3-Isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.953
leuD
3-Isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
 0.913
CAZ97933.1
The major facilitator superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients; Contains 11 transmembrane segments; Localized in the cytoplasmic membrane; Family membership.
 
  
 0.829
ilvD2
Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid; Binds a 4Fe-4S cluster; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the IlvD/Edd family.
 
  
 0.826
CAZ97935.1
Conserved protein belonging to a family of putative cyclases. These proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site. Localized in the cytoplasm.
 
     0.806
CAZ97932.1
NAD(P)-dependent oxidoreductase belonging to the GFO/IDH/MOCA family. Adopts a Rossmann fold. Localized in the cytoplasm; Specificity unclear.
 
  
 0.805
CAZ97934.1
Conserved hypothetical protein. Localized in the cytoplasm.
 
     0.804
ilvD1
Dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid; Binds a 4Fe-4S cluster; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the IlvD/Edd family.
 
  
 0.759
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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