STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srfADSurfactin synthetase thioesterase; Thioesterase involved in the biosynthesis of the antibiotic surfactin. Thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic; Localized in the cytoplasm; High confidence in function and specificity. (238 aa)    
Predicted Functional Partners:
CAZ94457.1
Type I polyketide synthases are modular enzymes involved in the synthesis of various polyketides. This enzyme encompasses five modules: beta-ketoacyl synthase (KS), acyltransferase (AC), dehydratase (DH), enoyl reductase (ER) and acyl carrier protein (ACP). This modular enzyme is homologous to mycocerosic acid synthase (EC 2.3.1.111). Binds 1 phosphopantetheine group covalently. Localized in the cytoplasmic membrane; Specificity unclear.
 
  
 0.988
ribAB
Riboflavin biosynthesis protein RibAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
   
    0.625
CAZ95078.1
Glycoside hydrolase belonging to the family GH16. The substrate specificity is unclear. Contains a central carbohydrate binding module of the family 6 (CBM6) and a C-terminal domain of unknown function. Features a uncleaved signal peptide; Specificity unclear.
  
     0.585
CAZ95408.1
Conserved protein belonging to the 4'-phosphopantetheinyl transferase family; The members of this family activates enzymes and carrier proteins, by transferring the phophopantethiene prosthetic group of coenzyme A to its attachment site (a serine residue). Many members of the family are small proteins that act on the acyl carrier protein involved in fatty acid biosynthesis; Uses magnesium ion as cofactor; Localized in the cytoplasm; Family membership.
  
  
 0.574
CAZ94458.1
Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis; Localized in the cytoplasm; Family membership.
 
   
 0.514
lamE
Endo-1,3-beta-glucanase, family GH64; Endo-1,3-beta-glucanase (Laminarinase) hydrolyzes the 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans. This laminarinase is a modular protein with a N-terminal catalytic module of the family 64 of glycoside hydrolases (GH64), a central carbohydrate binding module of the family 6 (CBM6) and a C-terminal conserved domain of unknown function. Features a signal peptide cleaved between the residues 20 and 21; Hypothetical protein.
  
     0.433
bglC
Endo-beta-1,4-glucanase, family GH5; BglC hydrolyzes the beta-1,4 linkages of carboxylmethylcellulose; Belongs to the family 5 of the glycoside hydrolases (GH5); Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 17 and 18; Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
     0.432
mdmC
MdmC is a 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics; Localized in the cytoplasm; High confidence in function and specificity.
 
     0.403
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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