STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hxlB3-Hexulose-6-phosphate isomerase catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate. Together with HxlA, may act as a formaldehyde detoxification system. It forms a homotetramer. Localized in the cytoplasm; High confidence in function and specificity. (194 aa)    
Predicted Functional Partners:
hxlA
3-Hexulose-6-phosphate synthase catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with HxlB, may act as a formaldehyde detoxification system. Localized in the cytoplasm; High confidence in function and specificity.
 
 0.999
CAZ96828.1
Sugar-phosphate isomerases catalyse the conversion of sugar-phosphate to another sugar-phosphate; Contains a Glucose-6-phosphate isomerase domain; Binds 1 iron ion per subunit; Belongs to the cupin superfamily, archaeal-type GPI family; Localized in the cytoplasm; Specificity unclear.
  
 
 0.919
pgiA
Glucose-6-phosphate isomerase is a dimeric enzyme that catalyses the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate in the second step of glycolysis (Embden-Meyerhof pathway) and in oxydative phase of pentose phosphate pathway. PgiA also is involved in the gluconeogenesis and in Pentose phosphate pathway; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the GPI family.
    
 0.916
pfp
Diphosphate-fructose-6-phosphate 1-phosphotransferase catalyzes the reversible phosphorylation of fructose-6-phosphate using pyrophoshate instead of ATP for phosphofructokinase (Pfk). Involved in glycolysis. It forms a homotetramer. Localized in the cytoplasm; High confidence in function and specificity.
    
 0.914
pfkA
6-Phosphofructokinase, isoenzyme 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
    
 0.914
fbpA
Fructose-1,6-bisphosphatase is involved in glycolysis / gluconeogenesis and in mannose and fructose metabolism. It removes one phosphate group from D-fructose 1,6-bisphosphate to form D-fructose 6-phosphate. The catalytic mechanism of FbpA is dependent of Mg2+; Belongs to the inositol polyphosphate 1 phosphatase like superfamily; Localized in the cytoplasm; High confidence in function and specificity.
   
 
 0.913
pfkB
6-Phosphofructokinase, isozyme 2; 6-Phosphofructokinase catalyzes the thirth step of glycolysis (Embden-Meyerhof pathway). It phosphoryles the D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. It is an allosteric homodimer enzyme. Because the reaction catalyzed by Phosphofructokinase is energetically very favorable, it is essentially irreversible; Belongs to the carbohydrate kinase PfkB family; Localized in the cytoplasm; High confidence in function and specificity.
   
 
  0.901
tktB
Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5- phosphate to an aldose receptor, such as ribose 5- phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. TK provides a link between the Embden-Meyerhof and pentose-phosphate (Non-oxidative phase) pathways; Uses calcium ion as a cofactor and thiamine diphosphate as prosthetic group; Localized in the cytoplasm; High confidence in function and specificity.
     
  0.900
tktA
Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5- phosphate to an aldose receptor, such as ribose 5- phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. TK provides a link between the Embden-Meyerhof and pentose-phosphate (Non-oxidative phase) pathways; Uses calcium ion as a cofactor and thiamine diphosphate as prosthetic group; Localized in the cytoplasm; High confidence in function and specificity.
     
  0.900
CAZ98078.1
The AraC-type transcriptional regulators are usually involved in the positive regulation of catabolic, metabolic and transport operons; Contains a C-terminal AraC-type HTH DNA-binding domain involved in the binding of the protein to the operator sequences in the DNA and a N-terminal domain presumed to interact with effector molecules and may be involved in dimerization; Localized in the cytoplasm; Family membership.
 
     0.633
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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