STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menCO-succinylbenzoate synthase; Enzyme involved in the third step of the menaquinone biosynthesis pathway from the chorismate. It converts the 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to O-succinylbenzoate (OSB); Uses the magnesium ion as cofactor; Belongs to the mandelate racemase/muconate lactonizing enzyme family; Localized in the cytoplasm; High confidence in function and specificity. (350 aa)    
Predicted Functional Partners:
menE
The O-succinylbenzoic acid-CoA ligase converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA) in the fourth step of the menaquinone (vitamin K2) biosynthesis pathway from chorismate; Contains an AMP-binding domain; Belongs to the ATP-dependent AMP-binding enzyme family; Localized in the cytoplasm; High confidence in function and specificity.
 
  0.999
menD
2-oxoglutarate decarboxylase/SHCHC synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
   
 0.799
CAZ98166.1
Peptidase, family U48; Conserved peptidase belonging to the family U48, which includes prenyl peptidases. Its exact specificity is unknown. Features eight transmembrane helices. Localized in the cytoplasmic membrane; Function unclear.
       0.791
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.783
menF
The isochorismate synthase, called also isochorismate mutase catalyses the conversion of chorismate to isochorismate, the first step in the biosynthesis of both respiratory chain components: menaquinone (MK, vitamin K2) and phylloquinone (vitamin K1); Localized in the cytoplasm; High confidence in function and specificity.
 
   
 0.761
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
   
 0.751
CAZ96926.1
DUF1599 family protein; Conserved protein containing two consecutive domains belonging to the DUF1599 family. Localized in the cytoplasm; Family membership.
  
     0.657
CAZ97805.1
Conserved hypothetical protein; Localized in the cytoplasm.
  
     0.595
CAZ98164.1
Conserved hypothetical protein; Possible fragment of 3-oxoacyl-[acyl-carrier protein] reductase; Putatively localized in the cytoplasm.
       0.533
CAZ95666.1
Conserved protein belonging to the family DUF177; Localized in the cytoplasm; Family membership.
  
     0.500
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.