STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (477 aa)    
Predicted Functional Partners:
sdhA
Succinate dehydrogenase is a complex containing three subunits: a flavoprotein, an iron-sulfur protein and cytochrome b-558. It is involved in the citrate cycle and catalyzes the reaction: succinate + acceptor = fumarate + reduced acceptor. It uses a FAD as a cofactor. SdhA is the flavoprotein subunit. Localized in the cytoplasm; High confidence in function and specificity.
 
 0.986
maeB
Bifunctional protein: Malic enzyme (N-terminal domain, 1 to 550) and Phosphate acetyl/butaryl transferase (C-terminal domain, 550 to 765); High confidence in function and specificity.
  
 
 0.974
sdhB
Succinate dehydrogenase is a complex containing three subunits: a flavoprotein, an iron-sulfur protein and cytochrome b-558. It is involved in the citrate cycle and catalyzes the reaction: succinate + acceptor = fumarate + reduced acceptor. It uses a FAD as a cofactor. SdhB is the iron-sulfur subunit. Localized in the cytoplasm; High confidence in function and specificity.
  
 0.968
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.966
gltA
The citrate synthase is the enzyme that catalyzes an important reaction in both energy generation and carbon assimilation, the synthesis of citrate from oxaloacetate and acetyl-CoA in an aldol condensation, that is the first reaction of the tricarboxylic acid cycle (Krebs' cycle). It can directly form a carbon-carbon bond in the absence of metal ion cofactors; Allosterically inhibited by NADH; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.922
sdhC
Succinate dehydrogenase is a complex containing three subunits: a flavoprotein, an iron-sulfur protein and cytochrome b-558. It is involved in the citrate cycle and catalyzes the reaction: succinate + acceptor = fumarate + reduced acceptor. It uses a FAD as a cofactor. SdhC is the cytochrome b558 subunit. It binds two hemes. Features five transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
     
  0.900
CAZ96456.1
Hypothetical membrane protein; Contains one N-terminal transmembrane segment; Localized in the cytoplasmic membrane; Hypothetical protein.
     
  0.900
fahA
Fumarylacetoacetase catalyses the hydrolytic cleavage of a carbon-carbon bond in fumarylacetoacetate to yield fumarate and acetoacetate as the final step in phenylalanine and tyrosine degradation. The products then join the citric acid cycle. It forms homodimer and binds one calcium ion and one magnesium ion as cofactors per subunit; Localized in the cytoplasm; Hypothetical protein.
  
 0.838
argH
Argininosuccinate lyase is involved in the eighth and last step of the arginine biosynthesis pathway. It converts the Omega-N-(L-arginino)succinate to fumarate and L-arginine; Belongs to the fumarate lyase family. Localized in the cytoplasm; High confidence in function and specificity.
   
 
0.829
aldA
Lactaldehyde dehydrogenase catalyze the NAD-dependent oxidation of lactaldehyde into lactate. This protein is a tetramer. AldA is involved in the catabolism of L-fucose and L-rhamnose and is induced by these sugars. In aerobic condition, the lactaldehyde is produced by the cleavage of L-fucose or L-rhamnose; Belongs to the aldehyde dehydrogenase fold family; Localized in the cytoplasm; High confidence in function and specificity.
   
 0.828
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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