STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ltaAThe L-allo-threonine aldolase is an enzyme involved in the Glycine metabolism. It converts the L-allo-Threonine and the threonine to glycine; Uses a pyridoxal phosphate group as cofactor; Localized in the cytoplasm; High confidence in function and specificity. (340 aa)    
Predicted Functional Partners:
gcvP
Glycine cleavage system, protein P component; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.949
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.931
thrC
The threonine synthase catalyzes the transformation of homoserine-phosphate into threonine; Uses the pyridoxal phosphate as cofactor (vitamin B6) attached to a conserved lysine residue; Belongs to the serine/threonine dehydratase family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.921
thrC-2
Threonine synthase is involved in the threonine biosynthesis pathway. It converts the O-phospho-L-homoserine to L-threonine. Belongs to the Pyridoxal-phosphate dependent enzyme family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.921
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.914
kblA2
Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
 
 0.908
kblA1
Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
 
 0.908
kblA3
Enzyme involved in the Glycine, serine and threonine metabolism, and in particular, in the glycine catabolism; Also called 2-amino-3-ketobutyrate coenzyme A ligase; Uses the Pyridoxal phosphate as cofactor; Belongs to the class II of the pyridoxal-phosphate-dependent aminotransferase family; Localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.908
CAZ97155.1
This enzyme belongs to the NAD-dependent epimerase/dehydratase family, which is included in the Rossmann fold Superfamily. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; Localized in the cytoplasm; Family membership.
    
 0.906
CAZ95549.1
NADP-dependent L-serine/L-allo-threonine dehydrogenase; Catalyzes the NADP-dependent oxidation of L-allo-threonine and L-serine; Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Localized in the cytoplasm; High confidence in function and specificity.
    
  0.905
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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