STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serA2D-3-phosphoglycerate dehydrogenase; SerA catalyzes the conversion of 3-phosphoglycerate to 3-phosphonooxypyruvate, which is the first step of the serine biosynthesis pathway. SerA2 is composed of a substrate-binding domain (D-isomer specific 2-hydroxyacid dehydrogenase family) and a NAD-binding domain (Rossman fold). Localized in the cytoplasm; High confidence in function and specificity. (316 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
 
 0.992
CAZ96283.1
NAD-dependent 2-hydroxyacid dehydrogenase which seems to be specific for the D-isomer of their substrate; Contains a NAD-binding domain; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family; Localized in the cytoplasm; Specificity unclear.
  
  
 
0.927
serB/serA1
Phosphoserine phosphatase / D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
0.921
gpmA
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
   
 0.910
gpmI
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
 0.903
udk
Uridine kinase (pyrimidine ribonucleoside kinase) is the rate-limiting enzyme in the pyrimidine salvage pathway. It catalyzes the reactions: ATP + uridine = ADP + UMP and ATP + cytidine = ADP + CMP. It forms a homotetramer and binds a ATP per subunit as cofactor. Localized in the cytoplasm; High confidence in function and specificity.
   
  0.660
metX
Homoserine O-acetyltransferase / Aspartokinase / Homoserine dehydrogenase; This enzyme is a modular protein with a homoserine O-acetyltransferase module (N-terminal) that catalyses the homoserine acetylation and belongs to the alpha/beta hydrolase fold family, an aspartate kinase module (central) that catalyzes the phosphorylation of aspartate and belongs to the amino acid kinase family and, in C- terminal part, a homoserine dehydrogenase module that catalyzes the NAD-dependent reduction of aspartate beta- semialdehyde into homoserine. This module is composed of a substrate-binding dom [...]
  
 
 0.655
thrA
ThrA is a fusion-protein between aspartate kinase I (N-terminal) and homoserine dehydrogenase I (C-terminal) involved in L-Lysine and L-threonine biosynthesis pathways. Aspartate kinase I converts L-aspartate to 4-phospho-L-aspartate and belongs to the amino acid kinase family. Homoserine dehydrogenase I converts the L-homoserine to L-aspartate 4-semialdehyde. Homoserine dehydrogenase I is composed of a substrate-binding domain belonging to Homoserine dehydrogenase family and a NAD-binding domain (Rossman fold). ThrA features also two central regulatory ACT domains; Localized in the cy [...]
  
 
 0.592
CAZ98252.1
Conserved hypothetical protein; Localized in the cytoplasm.
  
 
 0.575
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
 
   
 0.574
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.