STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ghrAGlyoxylate/hydroxypyruvate reductase A catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively; Contains a glycine-rich region located in the central section corresponding to the NAD-binding domain; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity. (309 aa)    
Predicted Functional Partners:
gyaR
Glyoxylate reductase converts, in presence of NAD+, the Glycolate into glyoxylate. GyaR is involved in the glyoxylate metabolism (conversion of lipids into glucids); Contains a glycine-rich region located in the central section corresponding to the NAD-binding domain; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
  
0.928
CAZ98106.1
Glyoxalase superfamily protein; Contains a signal peptide cleaved between the residues 20 and 21; Belongs to the Glyoxalase superfamily; Localized in the periplasmic space; Family membership.
 
  
 0.915
CAZ94628.1
Belongs to the xylose isomerase-like TIM barrel family. Exported by the twin-arginine translocation pathway signal; Specificity unclear.
  
 
  0.914
aldA-3
Lactaldehyde dehydrogenase is involved in the catabolism of L-fucose and L-rhamnose and is induced by these sugars. AldA catalyzes the NAD-dependent oxidation of lactaldehyde into lactate; Forms a tetramer; Belongs to the aldehyde dehydrogenase fold family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.913
CAZ95842.1
Oxydoreductase NADPH dependent; Belongs to the aldo/keto reductase 1 family; Localized in the cytoplasm; Family membership.
    
 0.910
hyiA
The Hydroxypyruvate isomerase catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the xylose isomerase-like TIM barrel family; Exported by the twin-arginine translocation pathway signal; High confidence in function and specificity.
    
  0.903
CAZ96362.1
Hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the xylose isomerase-like TIM barrel family; Exported by the twin-arginine translocation pathway signal; High confidence in function and specificity.
    
  0.903
dgoA
2-Dehydro-3-deoxy-6-phosphogalactonate aldolase catalyzes the third step of the D-galactonate catabolism: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. Belongs to the class I aldolase whose catalytic mechanism involves the formation of a Schiff-base intermediate between the substrate and the epsilon-amino group of a lysine residue. Localized in the cytoplasm; High confidence in function and specificity.
    
  0.903
eda
KHG/KDPG aldolase is a bifunctional enzyme catalyzing the interconversion of 4-hydroxy-2-oxoglutarate into pyruvate and glyoxylate (4-Hydroxy-2-oxoglutarate aldolase activity) and the interconversion of 6-phospho-2-dehydro-3-deoxy-D-gluconate into pyruvate and glyceraldehyde 3-phosphate (Phospho-2-dehydro-3-deoxygluconate aldolase activity). This enzyme is involved in the Entner-Doudoroff pathway and in the glyoxylate and dicarboxylate metabolism; Belongs to the class I aldolase whose catalytic mechanism involves the formation of a Schiff-base intermediate between the substrate and the [...]
    
  0.903
CAZ95591.1
Protein belonging to the Glyoxalase superfamily; Localized in the cytoplasm; Family membership.
    
 0.901
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.