STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uxuBD-mannonate oxidoreductase or Fructuronate reductase catalyzes the NAD-dependent reduction of fructuronate into mannonate; Belongs to the Long-chain mannitol dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity. (498 aa)    
Predicted Functional Partners:
scrK2
Fructokinase catalyzes the transfer of a phosphate group from ATP to convert the fructose to fructose-6-phosphate, which is an entry point into glycolysis (Embden-Meyerhof pathway) via conversion into glucose-6-phosphate; Belongs to the carbohydrate kinase PfkB superfamily, bacterial fructokinase family; Localized in the cytoplasm; Family membership.
  
 0.992
xylA-2
Xylose isomerase is involved in xylose metabolism. It catalyzes the conversion of D-xylose into D-xylulose. It forms a homotetramer and binds 2 magnesium ions per subunit. Localized in the cytoplasm; High confidence in function and specificity.
    
 0.914
scrK1
Fructokinase catalyzes the transfert of phosphate group from ATP to convert the fructose to fructose-6-phosphate, which is an entry point into glycolysis (Embden-Meyerhof pathway) via conversion into glucose-6-phosphate; Belongs to the carbohydrate kinase pfkB superfamily, bacterial fructokinase family; Localized in the cytoplasm; High confidence in function and specificity.
    
 0.909
uxuA2
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
 0.833
rbsC
Ribose ABC importer, permease component; Part of the binding-protein-dependent ABC transporter system for D-ribose. Probably responsible for the translocation of the substrate across the membrane; Contains seven transmembrane segments; Belongs to the binding-protein-dependent transport system permease family; Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
   
 0.827
algD
GDP-mannose 6-dehydrogenase catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid. In Pseudomonas aeruginosa, this activated sugar is the precursor for alginate polymerization. AlgD belongs to the UDP-glucose/GDP- mannose dehydrogenase family, a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate. Localized in the cytoplasm; High confidence in function and specificity.
     
 0.814
uxuA1
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
 0.814
rbsB
Ribose ABC importer, periplasmic component; RbsB is the D-ribose-binding protein involved in the high-affinity D-ribose membrane transport system; Belongs to the bacterial solute-binding protein 2 family; Seems to have a uncleavable signal sequence; Localized in the cytoplasmic membrane and exposed in the periplasmic space; High confidence in function and specificity.
 
    0.809
rbsA
Ribose ABC importer, ATPase component; Part of the ABC transporter complex RbsABCD involved in D-ribose import. RbsA is Responsible for energy coupling to the transport system; The complex is composed of two ATP-binding proteins, two transmembrane proteins (rbsC and rbsD) and a solute-binding protein (rbsB); Contains 2 ABC transporter domains; Belongs to the ABC transporter family, ribose importer subfamily; Localized in the cytoplasmic membrane as a peripheral membrane protein; High confidence in function and specificity.
 
   
 0.769
uxaA
Altronate hydrolase or Altronic acid hydratase converts the altronic acid to 2-keto-2-deoxygluconate; it is catalytically inactive in the absence of Fe2+, Mn2+, and beta-mercaptoethanol. Synergistic activation of enzyme is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre; Contains an N-terminal SAF domain; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.734
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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