STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAZ98411.1Macrolide-specific ABC exporter, ATPase component; This protein is the nucleotide-binding domain of the ABC transporters (ABC ATPase); Responsible for coupling the energy of ATP hydrolysis to conformational changes in the permease component (ABC membrane); Putatively involved in the macrolides resistance; Localized in the cytoplasm near of the cytoplasmic membrane by association with the ABC transporter permease component; Family membership. (247 aa)    
Predicted Functional Partners:
macB
Macrolide-specific ABC exporter, permease component; ABC (ATP-binding cassette) membrane domain possibly involved in the macrolides resistance; Contains four transmembrane segments; Belongs to the ABC transporter family; Localized in the cytoplasmic membrane; Family membership.
 
 0.997
CAZ96546.1
ABC exporter, permease component; ABC (ATP-binding cassette) membrane domain (subunit 1) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics, heavy metals or solvents across biological membranes; Contains four transmembrane segments; Belongs to the ABC transporter family; Localized in the cytoplasmic membrane; Family membership.
 
 0.986
CAZ96547.1
ABC exporter, permease component; ABC (ATP-binding cassette) membrane domain (subunit 2) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics, heavy metals or solvents across biological membranes; Contains four transmembrane segments; Belongs to the ABC transporter family; Localized in the cytoplasmic membrane; Family membership.
 
 0.986
CAZ96542.1
ABC exporter, permease component; ABC (ATP-binding cassette) membrane domain (subunit 1) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics, heavy metals or solvents across biological membranes; Contains four transmembrane segments; Belongs to the ABC transporter family; Localized in the cytoplasmic membrane; Family membership.
 
 0.985
CAZ96543.1
ABC exporter, permease component; ABC (ATP-binding cassette) membrane domain (subunit 2) possibly involved in the defense mechanisms by extrusion of a variety of compounds such as antibiotics, heavy metals or solvents across biological membranes; Contains four transmembrane segments; Belongs to the ABC transporter family; Localized in the cytoplasmic membrane; Family membership.
 
 0.984
macA
The membrane fusion proteins (MFP) belong to a multidrug efflux pump system that confer the resistance to compounds such as antibiotics (as macrolides), solvents or heavy metals; Proteins of the MFP family function as 'adaptors', connecting a ABC transporters, localized in the cytoplasmic membrane, with a porin or channel localized in outer membrane; The MFP proteins seem to be anchored in the cytoplasmique membrane by a N-terminal transmembrane region; Belongs to the type I secretion system; Family membership.
 
 0.965
CAZ98409.1
The outer membrane efflux proteins (OEP) are composed of two repeats of OEP domain to form a trimeric channel continuous, solvent-accessible conduit that spans both the outer membrane and periplasmic space; May be specialized for the signal peptide independent extracellular secretion of a variety of substrates in Gram-negative bacteria; Signal peptide cleaved between the residues 18 and 19; Localized in the outer membrane; Belongs to the type I secretion system; Family membership.
 
 
 0.922
CAZ98413.1
The sensor histidine kinase belongs to two-component signal transduction systems. It catalyzes the ATP dependent autophosphorylation of a conserved histidine in its phosphoacceptor domain and the signal dependent phosphorylation of a conserved aspartic acid present in the response regulator receiver domain; Contains four N-terminal transmembrane segments; Localized in the cytoplasmic membrane; Family membership.
 
     0.828
nrtA
Essential component of the nitrate-transporting system. May be the substrate-binding protein; Lipoprotein putatively anchored in the outer membrane or in the cytoplasmic membrane (or in both membranes) by its N-terminal lipidic residue (peripheral membrane protein); High confidence in function and specificity.
 
    
 0.680
lolC
Lipoprotein releasing system, permease component; Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the cytoplasmic membrane. Such a release is dependent of lolA and of the sorting-signal of the mature lipoprotein (absence of an Asp at position 2); Contains four transmembrane segments; Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
 
 0.660
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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