STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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gltTProton/sodium-glutamate symporter; Carrier protein which is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system. GltT participates in nutrient uptake; Forms a homotrimer; Contains six transmembrane helices; Localized in the cytoplasmic membrane; High confidence in function and specificity; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (428 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
       0.557
gltA-2
Glutamate synthase [NADPH] large chain; Glutamate synthase is a key enzyme in the early stages of the assimilation of ammonia. It is a complex iron-sulfur flavoprotein catalyzing the reductive transfer of the amido nitrogen from L-glutamine to 2-oxoglutarate to form two molecules of L-glutamate via intramolecular channelling of ammonia from the amidotransferase domain to the FMN-binding domain. Glutamate synthase forms an aggregate of 4 catalytic active heterodimers, consisting of a large and a small subunit (GltB). GltA binds as cofactors a 3Fe-4S cluster, a FAD and a FMN. Localized i [...]
     
 0.504
cstA
CstA is induced during carbon starvation and is positively regulated by the cyclic AMP (cAMP) and cAMP receptor protein complex. It is involved in peptide utilization; Contains 13 transmembrane helices; Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
  
 0.491
nhaC-2
NhaC is a Na+/H+ antiporter involved in pH homeostasis and sodium extrusion; Contains ten transmembrane helices; Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
  
 0.480
maeB
Bifunctional protein: Malic enzyme (N-terminal domain, 1 to 550) and Phosphate acetyl/butaryl transferase (C-terminal domain, 550 to 765); High confidence in function and specificity.
  
  
 0.459
metH-2
Methionine synthase, homocysteine-binding module; Methionine synthase or 5-methyltetrahydrofolate-homocysteine S-methyltransferase catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate; L-homocysteine is bound via the zinc atom; Uses the cobalamin (vitamin B12) and zinc as cofactors; This sequence corresponds to the homocysteine-binding domain (Hcy-binding domain) only; Belongs to the vitamin-B12 dependent methionine synthase family; Localize [...]
     
 0.441
CAZ95728.1
Sodium/hydrogen exchanger; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. This integral membrane protein also contains a C-terminal TrkA- N domain which binds NAD and adopts a Rossmann fold, Contains twelve transmembrane helices; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter family; Localized in the cytoplasmic membrane; Specificity unclear.
 
 
 
 0.427
CAZ95046.1
Sodium / alanine symporter; This permease transports alanine in association with sodium ions. It forms a channel through the cytoplasmic membrane, the interior face being hydrophilic to allow the passage of alanine molecules and sodium ions. Features eleven transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
  
 0.425
gltA
The citrate synthase is the enzyme that catalyzes an important reaction in both energy generation and carbon assimilation, the synthesis of citrate from oxaloacetate and acetyl-CoA in an aldol condensation, that is the first reaction of the tricarboxylic acid cycle (Krebs' cycle). It can directly form a carbon-carbon bond in the absence of metal ion cofactors; Allosterically inhibited by NADH; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.422
CAZ98763.1
Conserved amino acid transporter. Its exact specificity is unknown. Features twelve transmembrane helices. Localized in the cytoplasmic membrane; Family membership.
 
 
 0.415
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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